Role of endothelin receptor signalling in squamous cell carcinoma.
Role of endothelin receptor signalling in squamous cell carcinoma.
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DOI：
10.3892/ijo.2011.1258
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发表时间：
2012-04
影响因子：
5.2
通讯作者：
Kamisaki Y
中科院分区：
文献类型：
--
作者：
Ishimoto S;Wada K;Tanaka N;Yamanishi T;Ishihama K;Aikawa T;Okura M;Nakajima A;Kogo M;Kamisaki Y
内皮素在包括血管收缩在内的多种生理功能中起重要作用。最近的研究报道内皮素受体ETA和ETB在肺和皮肤肿瘤组织中高度表达。相比之下，关于内皮素信号传导在头颈部癌增殖中的报道很少。免疫组化结果显示，舌癌组织中内皮素受体ETA和ETB均过表达。ETA和ETB在培养的舌和食管鳞状细胞癌（SCC）细胞系中表达。当用ETA选择性拮抗剂（BQ123）或ETB选择性拮抗剂（BQ788）处理两种培养的细胞系时，观察到细胞生长的抑制。当用特异性siRNA处理SCC以抑制ETA或ETB时，观察到类似的结果。此外，还观察到ET受体拮抗剂和siRNA处理对丝裂原活化蛋白（MAP）激酶途径的抑制。这些结果表明，内皮素信号可能，部分，通过MAP激酶途径在SCC细胞生长中发挥重要作用。
Endothelin plays important roles in various physiological functions including vascular constriction. Recent studies reported that the endothelin receptors ETA and ETB are highly expressed in lung and skin tumor tissues. In contrast, there are few reports on endothelin signalling in the proliferation of head and neck cancer. We found that both ETA and ETB endothelin receptors were overexpressed in tumor cells of tongue cancer samples by immunohistochemistry. ETA and ETB were expressed in cultured lingual and esophageal squamous cell carcinoma (SCCs) cell lines. When both cultured cell lines were treated with an ETA selective antagonist (BQ123) or an ETB selective antagonist (BQ788), inhibition of cell growth was observed. Similar results were observed when SCCs were treated with specific siRNA for the suppression of ETA or ETB. Furthermore, inhibition of the mitogen-activated protein (MAP) kinase pathway by the treatments with ET receptor antagonists and siRNA was also observed. These results indicate that endothelin signalling may, in part, play important roles in cell growth in SCCs through the MAP kinase pathway.
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影响因子：
6.4
作者：
Awano, S;Dawson, LA;Usmani, BA
通讯作者：
Usmani, BA
影响因子：
8.4
作者：
Boldrini, L;Gisfredi, S;Fontanini, G
通讯作者：
Fontanini, G
DOI：
10.1165/ajrcmb.22.4.3795
发表时间：
2000-04-01
影响因子：
6.4
作者：
Ahmed, SI;Thompson, J;Woll, PJ
通讯作者：
Woll, PJ
DOI：
10.1046/j.0014-2956.2001.02486.x
发表时间：
2001-10-01
期刊：
EUROPEAN JOURNAL OF BIOCHEMISTRY
影响因子：
--
作者：
Cramer, H;Schmenger, K;Schroeder, C
通讯作者：
Schroeder, C
影响因子：
8.8
作者：
Asham E;Shankar A;Loizidou M;Fredericks S;Miller K;Boulos PB;Burnstock G;Taylor I
通讯作者：
Taylor I