Large-scale synthesis of thiolated Au25 clusters via ligand exchange reactions of phosphine-stabilized Au11 clusters
Large-scale synthesis of thiolated Au25 clusters via ligand exchange reactions of phosphine-stabilized Au11 clusters
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DOI：
10.1021/ja053915s
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发表时间：
2005-10-05
影响因子：
15
通讯作者：
Teranishi, T
中科院分区：
文献类型：
--
作者：
Shichibu, Y;Negishi, Y;Teranishi, T
膦稳定的Au 11团簇在氯仿中与谷胱甘肽（GSH）在水中在氮气气氛下反应。所得的Au：SG簇表现出与Au 25（SG）18相似的光吸收光谱，Au 25（SG）18是从化学制备的Au：SG簇中分离出的主要产物之一（Negishi，Y.等人，J. Am. Chem.Soc.2005，127，5261）。通过光学光谱、电喷雾电离质谱和聚丙烯酰胺凝胶电泳进行的严格表征证实了在有氧条件下通过配体交换反应在亚100 mg尺度上选择性地获得Au25（SG）18簇。配体交换策略为大规模合成巯基化Au 25团簇提供了一种实用、方便的方法。
Phosphine-stabilized Au11clusters in chloroform were reacted with glutathione (GSH) in water under a nitrogen atmosphere. The resulting Au:SG clusters exhibit an optical absorption spectrum similar to that of Au25(SG)18, which was isolated as one of the major products from chemically prepared Au:SG clusters (Negishi, Y. et al.J. Am. Chem.Soc.2005,127, 5261). Rigorous characterization by optical spectroscopy, electrospray ionization mass spectrometry, and polyacrylamide gel electrophoresis confirms that the Au25(SG)18clusters were selectively obtained on the sub-100 mg scale by ligand exchange reaction under aerobic conditions. The ligand exchange strategy offers a practical and convenient method of synthesizing thiolated Au25clusters on a large scale.