An optimized individual target brain in the talairach coordinate system
An optimized individual target brain in the talairach coordinate system
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DOI：
10.1006/nimg.2002.1084
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发表时间：
2002-10-01
期刊：
影响因子：
5.7
通讯作者：
Fox, P
中科院分区：
文献类型：
--
作者：
Kochunov, P;Lancaster, J;Fox, P
区域空间标准化的目标是通过扭曲个体三维大脑图像以匹配单个目标大脑的特征来消除个体三维大脑图像之间的解剖差异。目前的目标大脑要么是一个平均值，适合于低分辨率的大脑映射研究，要么是一个单一的大脑。虽然单个高分辨率的目标大脑是理想的，以匹配解剖细节，但它可能导致解剖研究中的偏差。提出了一种优化方法，以减少ICBM高分辨率脑模板（HRBT），在许多实验室中使用的高分辨率MRI靶脑图像的个体解剖偏差。在一组27名正常受试者的HRBT扭曲的所有图像。对位移场进行平均以计算用于优化的“最小变形目标”（MDT）变换。优化后，HRBT的最大解剖学变化见于右侧的上级中央前回和中央后回、右枕下叶、右后颞叶和侧脑室。与原始HRBT相比，优化的HRBT显示出更好的解剖学匹配的27个大脑。这通过脑组和优化HRBT之间的空间交叉相关性的改善来量化（P < 0.05）。该处理的预期用途是通过将HRBT优化到由100多名正常受试者组成的组来创建代表正常成人大脑解剖结构的数字体积图谱。(C)2002 Elsevier Science（美国）。
The goal of regional spatial normalization is to remove anatomical differences between individual three-dimensional brain images by warping them to match features of a single target brain. Current target brains are either an average, suitable for low-resolution brain mapping studies, or a single brain. While a single high-resolution target brain is desirable to match anatomical detail, it can lead to bias in anatomical studies. An optimization method to reduce the individual anatomical bias of the ICBM high-resolution brain template (HRBT), a high-resolution MRI target brain image used in many laboratories, is presented. The HRBT was warped to all images in a group of 27 normal subjects. Displacement fields were averaged to calculate the "minimal deformation target" (MDT) transformation for optimization. The greatest anatomical changes in the HRBT, following optimization, were observed in the superior precentral and postcentral gyri on the right, the right inferior occipital, the right posterior temporal lobes, and the lateral ventricles. Compared with the original HRBT, the optimized HRBT showed better anatomical matching to the group of 27 brains. This was quantified by the improvements in spatial cross-correlation and between the group of brains and the optimized HRBT (P < 0.05). An intended use of this processing is to create a digital volumetric atlas that represents anatomy of a normal adult brain by optimizing the HRBT to the group consisting of 100+ normal subjects. (C) 2002 Elsevier Science (USA).