Transcatheter arterial chemoembolization of liver tumors: Effects of embolization protocol on injectable volume of chemotherapy and subsequent arterial patency
Transcatheter arterial chemoembolization of liver tumors: Effects of embolization protocol on injectable volume of chemotherapy and subsequent arterial patency
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DOI：
10.1007/s00270-002-2524-6
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发表时间：
2003-03-01
影响因子：
2.9
通讯作者：
Choti, MA
中科院分区：
文献类型：
--
作者：
Geschwind, JFH;Ramsey, DE;Choti, MA
本研究的目的是确定经导管动脉化疗栓塞（TACE）方案是否影响注入肝脏的化疗总量以及随后的动脉通畅性。在一家机构，共160例原发性或继发性肝癌患者接受了3种不同的化疗栓塞方案治疗。对数据进行回顾性分析。第1组（n = 36）包括化疗、油和聚乙烯醇颗粒（PVA）的浆液，第2组（n = 91）包括化疗、油和PVA，第3组（n = 33）包括化疗、油和Gelfoam纱布。记录注入肝脏的化疗总体积。在随后的化疗栓塞期间确定动脉通畅性。第1组、第2组和第3组预期化疗总剂量的平均百分比分别为54.6%、75.3%和80.6%。第1组、第2组和第3组在随访血管造影时的动脉通畅率分别为56%、74%和81%。在TACE期间，浆液方案（组1）显著降低了动脉通畅性和化疗的可注射量。
The purpose of this study was to determine whether transcatheter arterial chemioembolization (TACE) protocol affects the total volume of chemotherapy injected into the liver as well as subsequent arterial patency. A total of 160 patients with primary or secondary liver cancer were treated with 3 different chemoembolization protocols at a single institution. Data were analyzed retrospectively. Group 1 (n = 36) consisted of slurry of chemotherapy, oil and polyvinyl alcohol particles (PVA), group 2 (n = 91), chemotherapy and oil followed by PVA, and group 3 (n = 33), chemotherapy and oil followed by Gelfoam pledgets. The total volume of chemotherapy injected into the liver was recorded. Arterial patency was determined during subsequent chemoembolizations. The mean percentage of total intended chemotherapy dose administered was 54.6% for group 1, 75.3% for group 2, and 80.6% for group 3. Arterial patency at follow-up angiography was 56% for group 1, 74% for group 2, and 81% for group 3. The slurry protocol (group 1) significantly reduced arterial patency and injectable volume of chemotherapy during TACE.