Relationship of Wallerian degeneration to regrowing axons.
Relationship of Wallerian degeneration to regrowing axons.
复制标题
华勒变性与轴突再生的关系。
DOI：
10.1097/00005072-199111000-00002
复制
发表时间：
1991
影响因子：
3.2
通讯作者：
Collins,GH
中科院分区：
文献类型：
--
作者：
West,NR;Collins,GH
由于沃勒变性在神经系统再生的顺序中构成了一个非常重要和不可避免的位置，我们已经扩展了我们对这一过程的观察，因为它发生在我们的大鼠脊髓损伤的低温模型中。在以前的研究中，我们已经观察到基本上没有增长到沃勒区，尽管有大量的轴突再生通过受伤的地区。在本研究中，我们已经研究了电子显微镜下的沃勒变性及其接口与轴突从受伤的地区。在沃勒区，我们的观察结果不仅证实了许多以前的研究者，但提出了一个有序的序列的变化，在第一个60天的损伤后，开始与相对组织保存，然后耗尽退化轴浆，细胞外沉积的髓鞘和发展的细胞反应。与细胞反应相关的是大星形胶质细胞的发育，其可以在无髓鞘和薄髓鞘轴突附近发现。有了这个有限的证据支持轴突生长在沃勒区，它建议，进一步扩大这种细胞基质应该提供显着的支持再生轴突。
Because Wallerian degeneration constitutes a highly significant and unavoidable position in the sequence of nervous system regeneration we have extended our observations regarding this process as it occurs in our cryogenic model of spinal cord injury in the rat. In previous studies we have observed essentially no growth into the Wallerian zone despite a significant amount of axonal regrowth through the injured region. In the present study we have examined by electron microscopy the Wallerian degeneration and its interface with the axons from the injured region. In the Wallerian region our observations have not only confirmed those of many previous investigators but have suggested an orderly sequence of changes during the first 60 days post-injury, beginning with relative tissue preservation followed by depletion of degenerating axoplasm, extracellular deposition of myelin and the development of a cellular reaction. Associated with the cellular reaction is the development of large astrocytic cells which can be found adjacent to unmyelinated and thinly myelinated axons. With this limited evidence of support for axonal growth in the Wallerian zone it is suggested that further expansion of this cellular matrix should provide significant support to regrowing axons.