p-Tyrosol Enhances the Production of New Neurons in the Hippocampal CA1 Field after Transient Global Cerebral Ischemia in Rats
p-Tyrosol Enhances the Production of New Neurons in the Hippocampal CA1 Field after Transient Global Cerebral Ischemia in Rats
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DOI：
10.1007/s10517-019-04679-7
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发表时间：
2019-12-01
影响因子：
0.7
通讯作者：
Plotnikov, M. B.
中科院分区：
文献类型：
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作者：
Khodanovich, M. Yu.;Kisel, A. A.;Plotnikov, M. B.
本研究旨在评估p-酪醇对成年雄性Wistar大鼠暂时性全脑缺血模型的再生作用，该模型通过可逆闭塞源自主动脉弓的三条主要血管并向大脑供血。手术后10天内以20mg /kg的剂量给药对酪醇。在本模型损伤易感海马CA1区评估NeuN（+）成熟神经元的死亡和新形成的DCX+神经元的数量。我们发现缺血导致海马CA1区超过50%的成熟神经元死亡(p
This study aimed at assessing the regenerative effect of p-tyrosol in transient global cerebral ischemia modeled in adult male Wistar rats by reversible occlusion of the three major vessels originating from the aortic arch and supplying the blood to the brain. p-Tyrosol was administered intraperitoneally in a dose of 20 mg/kg over 10 days after surgery. The death of NeuN(+) mature neurons and the number of newly formed DCX+ neurons were assessed in the CA1 field of the hippocampus that is highly susceptible to damage in this model. We found that ischemia induced death of more than 50% mature neurons in the hippocampal CA1 field (p