In vitro screening batteries for neurotoxicants.
In vitro screening batteries for neurotoxicants.
复制标题
体外筛选电池中的神经毒物。
作者：
B. Veronesi
人们广泛认识到开发、验证和利用体外模型来测试化学品的神经毒性潜力的必要性。本讲座讨论了使用细胞和组织培养的主要优点、适合神经毒性研究的各种体外模型，以及机械模型和筛选模型之间的区别。讨论了设计筛选电池来评估神经毒物的注意事项。还介绍了适当的电池模型和终点（即细胞毒性和神经毒性）的选择以及电池设计中的技术考虑等主题。
The need to develop, validate and utilize in vitro models to test chemicals for neurotoxic potential is widely appreciated. This lecture discusses the major advantages of using cell and tissue culture, the various in vitro models amenable for neurotoxicity studies, and the distinction between mechanistic and screening models. Considerations for designing screening batteries to evaluate neurotoxicants are discussed. Topics such as choice of appropriate cell models and endpoints (i.e., cytotoxic and neurotoxic), and technical considerations in the design of the battery are also presented.