Histopathological features of sinonasal inverted papillomas in chinese patients
Histopathological features of sinonasal inverted papillomas in chinese patients
复制标题
中国患者鼻窦内翻性乳头状瘤的组织病理学特征。
DOI：
10.1002/lary.25694
复制
发表时间：
2016-04-01
期刊：
影响因子：
2.6
通讯作者：
Wang, De Yun
中科院分区：
文献类型：
--
作者：
Zhao, Li;Li, Chun Wei;Wang, De Yun
目的/假设鼻内翻性乳头状瘤（IP）是一种复发率很高的良性肿瘤。白种人研究中已报告了 IP 炎症的证据。本研究旨在探讨中国IP患者的组织病理学模式及其与临床特征的关联。研究设计基础科学研究。方法取自50例中国单侧IP患者的IP组织。 17 名健康受试者的下鼻甲粘膜活组织检查用作对照。评估上皮重塑和炎症细胞浸润的组织学模式和严重程度，并分析其与临床特征的关联。结果 31% 的 IP 标本被分类为 I 级（轻度重塑），49% 为 II 级（中度和重度重塑）。 14 名患者 (28%) 发现伴随炎症性鼻息肉。复发性 IP 与 II 级密切相关（比值比：5.81，95% 置信区间：1.34-25.18）。除CD4(+) T细胞外，腹腔注射中中性粒细胞、巨噬细胞、嗜酸性粒细胞、CD8(+) T细胞和FoxP3(+) T-reg细胞的数量均显着升高。其中，中性粒细胞是 IP 中的主要细胞类型。结论炎症可能在 IP 中具有潜在作用，并且较高级别的上皮重塑与 IP 的复发相关。证据水平NA Laryngoscopy，126：E141-E147，2016
Objectives/HypothesisNasal inverted papilloma (IP) is a benign tumor with high recurrence rates. Evidence of inflammation has been reported in IP in Caucasian studies. This study aimed to investigate the histopathological patterns and their associations with clinical characteristics in Chinese patients with IP.Study DesignBasic science study.MethodsIP tissues were obtained from 50 Chinese patients with unilateral IPs. Biopsies of inferior turbinate mucosa from 17 healthy subjects were used as controls. The histological patterns and severity of epithelial remodeling and inflammatory cell infiltration were evaluated and analyzed for associations with clinical characteristics.ResultsThirty-one percent of IP specimens were classified as grade I (mild remodeling) and 49% as grade II (moderate and severe remodeling). Concomitant inflammatory nasal polyps were found in 14 patients (28%). Recurrent IP was strongly associated with grade II (odds ratio: 5.81, 95% confidence interval: 1.34-25.18). Except CD4(+) T cells, quantities of neutrophils, macrophages, eosinophils, CD8(+) T cells, and FoxP3(+) T-reg cells were significantly elevated in IP. Of these, neutrophils were the predominant cell type in IP.ConclusionsInflammation may have potential roles in IPs and the higher grade of epithelial remodeling was associated with the recurrence of IPs.Level of EvidenceNA Laryngoscope, 126:E141-E147, 2016