A direct hepatotoxic effect of valproic acid.
A direct hepatotoxic effect of valproic acid.
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丙戊酸具有直接肝毒性作用。
DOI：
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发表时间：
1979
期刊：
影响因子：
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通讯作者：
L. W. McLain
中科院分区：
文献类型：
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作者：
N. Sussman;L. W. McLain
9例接受丙戊酸治疗的患者出现血浆纤维蛋白原浓度低和其他肝功能异常。一些患者还出现血小板计数低和出血时间延长。停药或减量后，异常值迅速恢复正常。肝功能异常与直接的剂量相关肝毒性一致。
Nine patients treated with valproic acid had low plasma fibrinogen concentration and other liver function abnormalities. Several patients also had a low platelet count and prolonged bleeding time. The abnormal values returned promptly to normal when the drug therapy was discontinued or the dosage reduced. The liver function abnormalities are consistent with a direct, dose-related hepatotoxicity.