Mapping the evolving definitions of translational research.
Mapping the evolving definitions of translational research.
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DOI：
10.1017/cts.2016.10
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发表时间：
2017-02
影响因子：
2.6
通讯作者：
Starren JB
中科院分区：
文献类型：
--
作者：
Fort DG;Herr TM;Shaw PL;Gutzman KE;Starren JB
对翻译研究定义的系统回顾与分析。最终的语料库由33篇论文组成，每篇论文至少由2名评审员阅读。定义被映射到一套共同的研究过程，以供介绍和分析。论文和定义的影响力进一步评估使用引文分析和凝聚聚类。所有定义都映射到共同的研究过程，揭示了每个过程的最常见的标签。聚集聚类揭示了3大家族的定义。引文分析表明，每个家族的原创论文被引用的次数比其他任何成员都多10倍。虽然定义之间的一致性很小，但我们能够确定一个新兴的共识5阶段（T0-T4）定义的翻译研究。T1涉及将基础研究的想法带到人类早期测试的过程。T2涉及建立人体有效性和临床指南。T3主要侧重于实施和传播研究，而T4则侧重于人口中的成果和有效性。T0涉及的研究，如全基因组关联研究，这些研究可以追溯到基础研究。我们使用系统的回顾和分析，以确定翻译研究阶段的定义之间正在出现的共识。
Systematic review and analysis of definitions of translational research. The final corpus was comprised of 33 papers, each read by at least 2 reviewers. Definitions were mapped to a common set of research processes for presentation and analysis. Influence of papers and definitions was further evaluated using citation analysis and agglomerative clustering. All definitions were mapped to common research processes, revealing most common labels for each process. Agglomerative clustering revealed 3 broad families of definitions. Citation analysis showed that the originating paper of each family has been cited ~10 times more than any other member. Although there is little agreement between definitions, we were able to identify an emerging consensus 5-phase (T0–T4) definition for translational research. T1 involves processes that bring ideas from basic research through early testing in humans. T2 involves the establishment of effectiveness in humans and clinical guidelines. T3 primarily focuses on implementation and dissemination research while T4 focuses on outcomes and effectiveness in populations. T0 involves research such as genome-wide association studies which wrap back around to basic research. We used systematic review and analysis to identify emerging consensus between definitions of translational research phases.