Players in Mitochondrial Dynamics and Female Reproduction.
Players in Mitochondrial Dynamics and Female Reproduction.
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DOI：
10.3389/fmolb.2021.717328
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发表时间：
2021
影响因子：
5
通讯作者：
Cao Y
中科院分区：
文献类型：
--
作者：
Zou W;Ji D;Zhang Z;Yang L;Cao Y
线粒体动力学（裂变和融合）是线粒体代谢功能、线粒体重新分布和线粒体质量控制的重要生理过程。多种蛋白质参与调节线粒体动力学。这些蛋白质的异常表达会干扰线粒体动力学并诱发一系列疾病。近年来已开发出多种治疗方法来治疗相关疾病，但其疗效有限。与此同时，线粒体动力学在女性生殖功能中的作用越来越受到人们的关注，包括卵母细胞的发育和成熟、受精和胚胎发育。在这里，我们回顾了线粒体动力学、参与线粒体动力学的蛋白质以及原发性线粒体动力学功能障碍引起的疾病的重要性。我们总结了遗传性线粒体融合裂变异常的最新治疗方法，并回顾了女性生殖线粒体动力学的最新进展。
Mitochondrial dynamics (fission and fusion) are essential physiological processes for mitochondrial metabolic function, mitochondrial redistribution, and mitochondrial quality control. Various proteins are involved in regulating mitochondrial dynamics. Aberrant expression of these proteins interferes with mitochondrial dynamics and induces a range of diseases. Multiple therapeutic approaches have been developed to treat the related diseases in recent years, but their curative effects are limited. Meanwhile, the role of mitochondrial dynamics in female reproductive function has attracted progressively more attention, including oocyte development and maturation, fertilization, and embryonic development. Here, we reviewed the significance of mitochondrial dynamics, proteins involved in mitochondrial dynamics, and disorders resulting from primary mitochondrial dynamic dysfunction. We summarized the latest therapeutic approaches of hereditary mitochondrial fusion–fission abnormalities and reviewed the recent advances in female reproductive mitochondrial dynamics.
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影响因子：
30.8
作者：
Abrams AJ;Hufnagel RB;Rebelo A;Zanna C;Patel N;Gonzalez MA;Campeanu IJ;Griffin LB;Groenewald S;Strickland AV;Tao F;Speziani F;Abreu L;Schüle R;Caporali L;La Morgia C;Maresca A;Liguori R;Lodi R;Ahmed ZM;Sund KL;Wang X;Krueger LA;Peng Y;Prada CE;Prows CA;Schorry EK;Antonellis A;Zimmerman HH;Abdul-Rahman OA;Yang Y;Downes SM;Prince J;Fontanesi F;Barrientos A;Németh AH;Carelli V;Huang T;Zuchner S;Dallman JE
通讯作者：
Dallman JE
影响因子：
15.1
作者：
Charif M;Wong YC;Kim S;Guichet A;Vignal C;Zanlonghi X;Bensaid P;Procaccio V;Bonneau D;Amati-Bonneau P;Reynier P;Krainc D;Lenaers G
通讯作者：
Lenaers G
影响因子：
11.2
作者：
Amati-Bonneau, P;Guichet, A;Reynier, P
通讯作者：
Reynier, P
影响因子：
9.3
作者：
Basso, Valentina;Marchesan, Elena;Ziviani, Elena
通讯作者：
Ziviani, Elena
影响因子：
3.5
作者：
Ban T;Heymann JA;Song Z;Hinshaw JE;Chan DC
通讯作者：
Chan DC