Comparison of clinical symptoms and bioimpedance to pulmonary capillary wedge pressure in heart failure.
Comparison of clinical symptoms and bioimpedance to pulmonary capillary wedge pressure in heart failure.
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心力衰竭临床症状及肺毛细血管楔压生物阻抗的比较。
DOI：
10.1016/j.ahjo.2022.100133
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Alvis,Bret
中科院分区：
文献类型：
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作者：
Polcz,Monica;Huston,Jessica;Breed,Meghan;Case,Marisa;Leisy,Philip;Schmeckpeper,Jeffrey;Vaughn,Lexie;Sobey,JennaHelmer;Brophy,Colleen;Lindenfeld,JoAnn;Hocking,Kyle;Alvis,Bret
简介心力衰竭的临床症状通常包括疲劳、水肿和呼吸短促。不幸的是，事实证明临床监测在预测充血和住院需要方面并不可靠。生物传感可穿戴设备已被开发为临床体征和症状的潜在辅助手段，可在充血变得严重之前检测到充血，从而防止心力衰竭住院。假设心力衰竭的临床体征和症状将与胸部生物阻抗测量 (ZOE®) 和肺毛细血管楔压 (PCWP) 相关。方法前瞻性招募了 155 名接受右心导管插入术 (RHC) 的受试者。获得Zo值（欧姆），估计颈静脉压（JVP），对所有受试者进行水肿分级，并评估呼吸短促（SOB）。 RHC 由预定的心脏病专家按常规进行。进行单向方差分析来评估变量之间的关系。使用 Pearson 相关系数来比较 Zo 值和 PCWP。结果估计的 JVP (cmH2O) (p = 0.65，n = 110) 和水肿评分 (p = 0.12，n = 110) 均未显示与 PCWP 存在显着关系。主观 SOB 的存在也没有表明与 PCWP 存在显着关联（p = 0.99，n = 110）。 ZOE® 和 PCWP 之间没有相关性（r = −0.08，p = 0.56，n = 56）。结论这些发现支持监测心力衰竭患者的传统措施有限的观点。
IntroductionClinical symptoms of heart failure commonly include fatigue, edema, and shortness of breath. Unfortunately, clinical monitoring has proven unreliable in predicting congestion and the need for hospitalization. Biosensing wearables have been developed as a potential adjunct to clinical signs and symptoms to detect congestion before it becomes severe thus preventing a heart failure hospitalization.HypothesisClinical signs and symptoms of heart failure will correlate with thoracic bioimpedance measurements (ZOE®) and pulmonary capillary wedge pressure (PCWP).MethodsOne hundred and fifty-five subjects undergoing right heart catheterization (RHC) were prospectively enrolled. A Zo value (ohms) was obtained, jugular venous pressure (JVP) was estimated, edema graded, and shortness of breath (SOB) assessed in all subjects. RHC was performed by a scheduled cardiologist per routine. One-way ANOVA was performed to assess the relationship between variables. A Pearson correlation coefficient was used to compare the Zo value and PCWP.ResultsNeither estimated JVP (cmH2O) (p = 0.65, n = 110) nor edema scores (p = 0.12, n = 110) demonstrated a significant relationship to PCWP. The presence of subjective SOB also did not demonstrate a significant association with PCWP (p = 0.99, n = 110). There was no correlation between ZOE® and PCWP (r = −0.08, p = 0.56, n = 56).ConclusionsThese findings support the idea that traditional measures for monitoring heart failure patients are limited.