AMPK/Mitochondria in Metabolic Diseases
AMPK/Mitochondria in Metabolic Diseases
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DOI：
10.1007/978-3-319-43589-3_6
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发表时间：
2016-01-01
期刊：
影响因子：
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通讯作者：
Roman-Malo, Lourdes
中科院分区：
文献类型：
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作者：
Bullon, Pedro;Marin-Aguilar, Fabiola;Roman-Malo, Lourdes
营养的获取是我们生命中最重要的任务。能量是生命进化的核心；这是诱导选择适应性更强和能量效益更高的物种的一个方面。如今，在我们的现代社会，事情已经发生了变化。高比例的人可以获得大量的食物，肥胖成为我们社会的病理特征之一。能量主要是在线粒体中通过产生ATP的内膜转移质子获得的。ATP （ATP ADP +磷酸）的合成和降解的精确调节对所有形式的生命都是必不可少的。这项任务是由5'腺苷单磷酸活化蛋白激酶（AMPK）完成的。mtDNA高度暴露于氧化损伤，可能在人类健康和疾病中发挥核心作用。这种高潜在的异常率是由一种最复杂的机制控制的：自噬。AMPK似乎是参与多种细胞机制的关键细胞能量传感器，对于具有良好的代谢稳态以面对所有攻击和启动炎症反应至关重要。因此，它的紊乱与多种疾病有关。最近的研究结果支持AMPK在炎症和免疫中的作用，如代谢综合征、肥胖和糖尿病。所有这些代谢紊乱都被认为是流行病，需要适当的控制和预防。深化致病机制是实现这一目标的重要途径之一。线粒体和AMPK是其发生的关键因素，它们的知识和研究使我们能够更好地管理。发现和使用能够调节它们的药物对于改善我们管理代谢紊乱的方式是必不可少的。
The obtaining of nutrients is the most important task in our lives. Energy is central to life's evolutions; this was one of the aspect that induced the selection of the more adaptable and more energetically profitable species. Nowadays things have changed in our modern society. A high proportion of people has access to plenty amount of food and the obesity appear as one of the pathological characteristics of our society. Energy is obtained essentially in the mitochondria with the transfer of protons across the inner membrane that produce ATP. The exactly regulation of the synthesis and degradation of ATP (ATP ADP + phosphate) is essential to all form of life. This task is performed by the 5' adenosine monophosphate-activated protein kinase (AMPK). mtDNA is highly exposed to oxidative damage and could play a central role in human health and disease. This high potential rate of abnormalities is controlled by one of the most complex mechanism: the autophagy. AMPK appears to be the key cellular energy sensor involved in multiple cellular mechanisms and is essential to have a good metabolic homeostasis to face all the aggression and start the inflammatory reaction. Therefore its disturbances have been related with multiple diseases. Recent findings support the role of AMPK in inflammation and immunity such as Metabolic Syndrome, Obesity and Diabetes. All these Metabolic Disorders are considered pandemics and they need an adequate control and prevention. One important way to achieve it is deepen in the pathogenic mechanisms. Mitochondria and AMPK are the key elements through which it happen, their knowledge and research allow us to a better management. The discovery and use of drugs that can modulate them is imperative to improve our way of manage the metabolic disorders.