GSH-triggered release of sulfur dioxide gas to regulate redox balance for enhanced photodynamic therapy
GSH-triggered release of sulfur dioxide gas to regulate redox balance for enhanced photodynamic therapy
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GSH触发释放二氧化硫气体以调节氧化还原平衡以增强光动力疗法
DOI：
10.1039/d0cc00470g
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发表时间：
2020
影响因子：
4.9
通讯作者：
Xiao Chunsheng
中科院分区：
文献类型：
--
作者：
Zhang Yu;Shen Wei;Zhang Peng;Chen Li;Xiao Chunsheng
在此，探索了一种有前途的策略，通过同时消耗GSH和释放SO2气体来调节肿瘤细胞中的氧化还原平衡，用于增强光动力治疗。光敏剂装载有响应于细胞中过表达的GSH而释放SO2气体的载体。SO2不仅诱导细胞凋亡，而且增加细胞内ROS水平。同时，负载的光敏剂也可在光照下产生ROS，导致细胞凋亡或坏死。
Herein, a promising strategy is explored to regulate redox balance in tumor cells by simultaneously consuming GSH and releasing SO2 gas for enhanced photodynamic therapy. The photosensitizer is loaded with a carrier that releases SO2 gas in response to GSH overexpressed in the cell. SO2 was found not only to induce cell apoptosis but also increase the intercellular ROS level. Meanwhile, the loaded-photosensitizers could also generate ROS with light irradiation, resulting in apoptosis or necrosis of cells.