KLF2 in Regulation of NF-κB-Mediated Immune Cell Function and Inflammation.
KLF2 in Regulation of NF-κB-Mediated Immune Cell Function and Inflammation.
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DOI：
10.3390/ijms18112383
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发表时间：
2017-11-10
影响因子：
5.6
通讯作者：
Das H
中科院分区：
文献类型：
--
作者：
Jha P;Das H
KLF2(Kruppel-like factor2)是锌指转录因子家族的一员，对胚胎肺发育、内皮细胞功能以及T细胞和单核细胞静止状态的维持起着重要的调节作用。它在幼稚T细胞和单核细胞中表达，但在活化和分化过程中其表达水平下降。KLF2在各种炎症性疾病及其发病机制中也起着重要的调节作用。核因子-kappaB(NF-κB)是一种重要的炎症诱导物，炎症是通过多种促炎细胞因子、趋化因子和黏附分子的转录介导的。因此，转录因子KLF2和NF-κB都与相似的细胞功能及其维持有关。结果表明，KLF2调节大部分的NF-κB介导的活性。在这篇综述中，我们重点强调了KLF2在健康和疾病状态中的参与，以及它们如何与转录主调控因子NF-κB相互作用。
KLF2 (Kruppel-like factor 2) is a member of the zinc finger transcription factor family, which critically regulates embryonic lung development, function of endothelial cells and maintenance of quiescence in T-cells and monocytes. It is expressed in naïve T-cells and monocytes, however its level of expression decreases during activation and differentiation. KLF2 also plays critical regulatory role in various inflammatory diseases and their pathogenesis. Nuclear factor-kappaB (NF-κB) is an important inducer of inflammation and the inflammation is mediated through the transcription of several proinflammatory cytokines, chemokines and adhesion molecules. So, both transcriptional factors KLF2 and NF-κB are being associated with the similar cellular functions and their maintenance. It was shown that KLF2 regulates most of the NF-κB-mediated activities. In this review, we focused on emphasizing the involvement of KLF2 in health and disease states and how they interact with transcriptional master regulator NF-κB.
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DOI：
10.4049/jimmunol.1600206
发表时间：
2016-12-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Alberts-Grill N;Engelbertsen D;Bu D;Foks A;Grabie N;Herter JM;Kuperwaser F;Chen T;Destefano G;Jarolim P;Lichtman AH
通讯作者：
Lichtman AH
影响因子：
20.1
作者：
Atkins GB;Wang Y;Mahabeleshwar GH;Shi H;Gao H;Kawanami D;Natesan V;Lin Z;Simon DI;Jain MK
通讯作者：
Jain MK
影响因子：
3.3
作者：
Cernotta N;Clocchiatti A;Florean C;Brancolini C
通讯作者：
Brancolini C
DOI：
10.1073/pnas.95.14.8211
发表时间：
1998-07-07
影响因子：
11.1
作者：
Foxwell, B;Browne, K;Feldmann, M
通讯作者：
Feldmann, M
影响因子：
3.7
作者：
Ohshima D;Ichikawa K
通讯作者：
Ichikawa K