Cognitive Dysfunction Syndrome A Disease of Canine and Feline Brain Aging
Cognitive Dysfunction Syndrome A Disease of Canine and Feline Brain Aging
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DOI：
10.1016/j.cvsm.2012.04.003
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发表时间：
2012-07-01
影响因子：
1.9
通讯作者：
Araujo, Joseph A.
中科院分区：
文献类型：
--
作者：
Landsberg, Gary M.;Nichol, Jeff;Araujo, Joseph A.
脑老化是一种以认知功能受损为表现的退化过程；虽然不是所有的宠物都受到相同程度的影响，但一旦认知能力开始下降，它通常是一种进行性疾病。认知功能障碍综合征（CDS）的诊断是基于对行为体征的识别和排除可能模仿CDS或使其诊断复杂化的其他医学原因。药物、饮食和补充剂现在可能通过各种机制减缓CDS的进展，包括减少氧化应激和炎症或改善线粒体和神经元功能。此外，现有的治疗方法可能在一定程度上改善CDS的认知和临床症状。
Brain aging is a degenerative process manifest by impairment of cognitive function; although not all pets are affected at the same level, once cognitive decline begins it is generally a progressive disorder. Diagnosis of cognitive dysfunction syndrome (CDS) is based on recognition of behavioral signs and exclusion of other medical causes that might mimic CDS or complicate its diagnosis. Drugs, diets, and supplements are now available that might slow CDS progression by various mechanisms including reducing oxidative stress and inflammation or improving mitochondrial and neuronal function. Moreover, available therapeutics may provide some level of improvement in cognitive and clinical signs of CDS.