Short-Term Consequences of SARS-CoV-2-Related Pneumonia: A Follow Up Study.
Short-Term Consequences of SARS-CoV-2-Related Pneumonia: A Follow Up Study.
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DOI：
10.1007/s40292-021-00454-w
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发表时间：
2021-07
期刊：
影响因子：
--
通讯作者：
Rizzoni D
中科院分区：
文献类型：
--
作者：
Boari GEM;Bonetti S;Braglia-Orlandini F;Chiarini G;Faustini C;Bianco G;Santagiuliana M;Guarinoni V;Saottini M;Viola S;Ferrari-Toninelli G;Pasini G;Bonzi B;Desenzani P;Tusi C;Malerba P;Zanotti E;Turini D;Rizzoni D
该研究的目的是评估SARS-CoV-2相关肺炎的短期后果，也与基线时的放射学/实验室/临床风险指数有关。这项前瞻性随访队列研究包括2020年2月28日至4月30日在意大利布雷西亚蒙蒂基亚里医院内科病房住院的94名确诊COVID-19患者。患者患有COVID-19相关肺炎伴呼吸衰竭。193名幸存者中有94名接受出院后重新评估，平均4个月后。在1/4的患者中检测到肺纤维化的证据，如肺一氧化碳弥散量（DLCO）改变所示;在6-7%的患者中，改变被分类为中度/重度。我们还通过结构化问卷评估了生活质量：52%的患者仍然感到疲劳，36%的患者感到呼吸困难，10%的患者感到厌食，14%的患者感到味觉障碍或嗅觉丧失，31%的患者感到失眠，21%的患者感到焦虑。最后，我们评估了三个预后指标（Brixia放射学评分，Charlson Comorbid指数和4C死亡率评分）在预测疾病的临床后果方面的作用。所有这些都显著预测了短期肺部受累的程度。总之，我们的研究表明，SARS-CoV-2相关肺炎与相关的短期临床结果相关，无论是在症状的持续性方面还是在DLCO受损方面（可能发生肺纤维化的指标）;疾病的一些严重程度指数可能预测短期临床结果。需要进一步研究以确定这些表现是否会长期存在。
The aim of the study was to assess the short-term consequences of SARS-CoV-2-related pneumonia, also in relation to radiologic/laboratory/clinical indices of risk at baseline. This prospective follow-up cohort study included 94 patients with confirmed COVID-19 admitted to a medical ward at the Montichiari Hospital, Brescia, Italy from February 28th to April 30th, 2020. Patients had COVID-19 related pneumonia with respiratory failure. Ninety-four patients out of 193 survivors accepted to be re-evaluated after discharge, on average after 4 months. In ¼ of the patients an evidence of pulmonary fibrosis was detected, as indicated by an altered diffusing capacity of the lung for carbon monoxide (DLCO); in 6–7% of patients the alteration was classified as of moderate/severe degree. We also evaluated quality of life thorough a structured questionnaire: 52% of the patients still lamented fatigue, 36% effort dyspnea, 10% anorexia, 14% dysgeusia or anosmia, 31% insomnia and 21% anxiety. Finally, we evaluated three prognostic indices (the Brixia radiologic score, the Charlson Comorbidity Index and the 4C mortality score) in terms of prediction of the clinical consequences of the disease. All of them significantly predicted the extent of short-term lung involvement. In conclusion, our study demonstrated that SARS-CoV-2-related pneumonia is associated to relevant short-term clinical consequences, both in terms of persistence of symptoms and in terms of impairment of DLCO (indicator of a possible development of pulmonary fibrosis); some severity indices of the disease may predict short-term clinical outcome. Further studies are needed to ascertain whether such manifestations may persist long-term.
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影响因子：
8.3
作者：
Liu C;Ye L;Xia R;Zheng X;Yuan C;Wang Z;Lin R;Shi D;Gao Y;Yao J;Sun Q;Wang X;Jin M
通讯作者：
Jin M
DOI：
10.26355/eurrev_202011_23858
发表时间：
2020-01-01
影响因子：
3.3
作者：
Chieffo, D. P. R.;Delle Donne, V;Cauda, R.
通讯作者：
Cauda, R.
DOI：
10.1016/j.ijtb.2020.11.003
发表时间：
2021-07
期刊：
The Indian journal of tuberculosis
影响因子：
--
作者：
Rai DK;Sharma P;Kumar R
通讯作者：
Kumar R
影响因子：
12.7
作者：
Tomasoni, Daniele;Bai, Francesca;d'Arminio Monforte, Antonella
通讯作者：
d'Arminio Monforte, Antonella
影响因子：
8.9
作者：
Borghesi, Andrea;Maroldi, Roberto
通讯作者：
Maroldi, Roberto