DNA damage sensing by the ATM and ATR kinases.
DNA damage sensing by the ATM and ATR kinases.
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DOI：
10.1101/cshperspect.a012716
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发表时间：
2013-09-01
影响因子：
7.2
通讯作者：
Zou, Lee
中科院分区：
文献类型：
--
作者：
Marechal, Alexandre;Zou, Lee
在真核细胞中，基因组稳定性的维持依赖于细胞过程网络的协调作用，包括DNA复制、DNA修复、细胞周期进程等。由ATM和ATR激酶协调的DNA损伤反应（DDR）信号通路是该网络响应DNA损伤的中心调节器。ATM和ATR都是由DNA损伤和DNA复制应激激活的，但它们的DNA损伤特异性不同，它们的功能也不是冗余的。此外，ATM和ATR通常一起工作，以发出DNA损伤信号并调节下游过程。在这里，我们将讨论ATM和ATR如何感知DNA损伤、它们如何被DNA损伤激活以及它们如何协同作用来调节DDR的最新发现和当前模型。
In eukaryotic cells, maintenance of genomic stability relies on the coordinated action of a network of cellular processes, including DNA replication, DNA repair, cell-cycle progression, and others. The DNA damage response (DDR) signaling pathway orchestrated by the ATM and ATR kinases is the central regulator of this network in response to DNA damage. Both ATM and ATR are activated by DNA damage and DNA replication stress, but their DNA-damage specificities are distinct and their functions are not redundant. Furthermore, ATM and ATR often work together to signal DNA damage and regulate downstream processes. Here, we will discuss the recent findings and current models of how ATM and ATR sense DNA damage, how they are activated by DNA damage, and how they function in concert to regulate the DDR.