Electrophilic Aromatic Trifluoromethylthiolation with the Second Generation of Trifluoromethanesulfenamide
Electrophilic Aromatic Trifluoromethylthiolation with the Second Generation of Trifluoromethanesulfenamide
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DOI：
10.1055/s-0034-1379501
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发表时间：
2015-01-01
期刊：
影响因子：
2
通讯作者：
Billard, Thierry
中科院分区：
文献类型：
--
作者：
Alazet, Sebastien;Billard, Thierry
各种不同取代的芳香族和杂芳香族化合物的直接三氟甲硫基化可以通过第二代三氟甲次磺酰胺通过“弗里德尔-克来福特反应”进行。该反应需要温和的条件和催化量的质子酸或路易斯酸。即使对于带有失活取代基的芳族化合物，也获得了良好的结果。
Direct trifluoromethylthiolation of various aromatic and heteroaromatic compounds, variously substituted, can be performed with the second generation of trifluoromethanesulfenamide via a 'Friedel-Crafts-like reaction'. This reaction requires mild conditions with a catalytic amount of protic or Lewis acid. Good results have been obtained, even with aromatic compounds bearing deactivating substituents.