Endocannabinoids mediate the effects of acute stress and corticosterone on sex behavior
Endocannabinoids mediate the effects of acute stress and corticosterone on sex behavior
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DOI：
10.1210/en.2006-0740
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发表时间：
2007-02-01
期刊：
影响因子：
4.8
通讯作者：
Moore, Frank L.
中科院分区：
文献类型：
--
作者：
Coddington, Emma;Lewis, Christine;Moore, Frank L.
对于野生动物来说，生存取决于能够检测到危险并迅速做出反应，从危险（例如：G.明显的求偶）到生存导向的行为。当动物察觉到威胁或其他压力时，控制行为状态快速转换的激素或神经内分泌机制知之甚少。先前的研究与粗糙的皮肤蝾螈（Taricha granulosa），两栖动物模型，发现压力引起的男性性行为（抱抱）抑制涉及皮质酮（CORT），这种类固醇激素使用一种新的膜受体和调节反应的延髓神经元在clasp控制神经回路。我们提供的证据表明，这种快速抑制男性的性行为时，无论是急性应激或CORT管理，涉及激活内源性大麻素信号在后脑。在一系列行为研究中，大麻素拮抗剂AM281的施用阻断了暴露于急性应激或注射CORT对性活跃男性的抱握行为表现的抑制作用。类似地，在电生理学研究中，预先用AM 281处理阻断了CORT诱导的对扣合控制神经回路中的自发神经元活动和后脑神经元的感觉反应性的抑制。这些数据表明，在急性应激反应中，CORT浓度升高增加了后脑内源性大麻素信号，并通过调节延髓回路的兴奋性来改变性行为。
For animals in the wild, survival depends on being able to detect and respond rapidly to danger by switching from risky ( e. g. conspicuous courtship) to survival-oriented behaviors. Very little is known about the hormonal or neuroendocrine mechanisms that control the rapid switch in behavioral state that occurs when an animal detects threats or other stressors. Prior studies with rough-skinned newts ( Taricha granulosa), an amphibian model, found that stress-induced suppression of male sexual behaviors (amplectic clasping) involves corticosterone ( CORT) and that this steroid hormone uses a novel membrane receptor and modulates the responsiveness of medullary neurons in clasp-controlling neural circuits. We provide evidence that this rapid suppression of male sex behaviors, when induced by either acute stress or CORT administration, involves activation of endocannabinoids signaling in the hindbrain. In a series of behavioral studies, administration of a cannabinoid antagonist, AM281, blocked the suppressive effects of exposure to acute stress or an injection of CORT on the performance of clasping behaviors in sexually active males. Similarly, in electrophysiological studies, prior treatment with AM281 blocked CORT-induced suppression of spontaneous neuronal activity and sensory responsiveness of hindbrain neurons in clasp-controlling neural circuits. These data suggest that, in response to acute stress, elevated CORT concentration increases endocannabinoids signaling in the hindbrain and alters sexual behaviors by modulating the excitability of medullary circuits.