Mortality in US Army Gulf War veterans exposed to 1991 Khamisiyah chemical munitions destruction
Mortality in US Army Gulf War veterans exposed to 1991 Khamisiyah chemical munitions destruction
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DOI：
10.2105/ajph.2004.045799
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发表时间：
2005-08-01
影响因子：
12.7
通讯作者：
Page, WF
中科院分区：
文献类型：
--
作者：
Bullman, TA;Mahan, CM;Page, WF
目标。我们调查了1991年3月在伊拉克Khamisiyah拆除武器时，可能暴露于神经毒剂的美国陆军海湾战争退伍军人，是否有增加因特定原因死亡的风险。将100487名暴露的美国陆军海湾战争退伍军人与224980名未暴露的美国陆军海湾战争退伍军人的死因特异性死亡率进行比较。暴露量是根据国防部2000年烟柱模型确定的。相对风险估计来源于Cox比例风险模型。大多数与疾病相关的死亡风险对于暴露和未暴露的退伍军人是相似的。然而，暴露的退伍军人脑癌死亡风险增加（相对危险度[RR]= 1.94； 95%可信区间[Cl]= 1.12, 3.34）。与所有未暴露的退伍军人分别比较，暴露2天及以上的退伍军人脑癌死亡风险大于暴露1天的退伍军人（RR=3.26; 95% Cl = 1.33, 7.96； RR= 1.72; 95% Cl =0.95,3.10）。在哈米西亚接触化学弹药可能与脑癌死亡风险增加有关。需要进一步的研究来证实这一发现。
Objectives. We investigated whether US Army Gulf War veterans who were potentially exposed to nerve agents during the March 1991 weapons demolitions at Khamisiyah, Iraq, are at increased risk of cause-specific mortality.Methods. The cause-specific mortality of 100487 exposed US Army Gulf War veterans was compared with that of 224980 unexposed US Army Gulf War veterans. Exposure was determined with the Department of Defense 2000 plume model. Relative risk estimates were derived from Cox proportional hazards models.Results. The risks of most disease-related mortality were similar for exposed and unexposed veterans. However, exposed veterans had an increased risk of brain cancer deaths (relative risk [RR]= 1.94; 95% confidence interval [Cl]= 1.12, 3.34). The risk of brain cancer death was larger among those exposed 2 or more days than those exposed 1 day when both were compared separately to all unexposed veterans (RR=3.26; 95% Cl = 1.33, 7.96; RR= 1.72; 95% Cl =0.95,3.10, respectively).Conclusions. Exposure to chemical munitions at Khamisiyah may be associated with an increased risk of brain cancer death. Additional research is required to confirm this finding.