Magnetoencephalography Language Mapping Using Auditory Memory Retrieval and Silent Repeating Task.
Magnetoencephalography Language Mapping Using Auditory Memory Retrieval and Silent Repeating Task.
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DOI：
10.1097/wnp.0000000000000947
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发表时间：
2024-02-01
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影响因子：
--
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中科院分区：
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本研究的目的是（1）检测听觉记忆提取和无声重复（AMRSR）任务中脑磁图诱发反应的时空图，并确定语言的半球优势;（2）评价AMRSR任务在Wernicke和Broca区定位中的准确性。在30例脑肿瘤和/或癫痫患者中，AMRSR任务被用来诱发脑磁图反应。我们应用快速矢量时空分析与最小L1范数源成像方法的脑磁图反应定位的大脑区域诱发的AMRSR任务。基于Fast-Vector的时空分析发现，在后上级颞回约300至500 ms处有一致的激活，在额叶皮层（盖部和/或三角部）约600至900 ms处有另一激活，分别位于Wernicke区（BA 22）和Broca区（BA 44和BA 45）。由AMRSR任务引起的语言优势半球的laterization是可比的结果从听觉双耳分听任务的结果给同一个病人，除了AMRSR是更敏感的双边语言laterization的情况下，找到韦尼克和布罗卡区。对于所有成功完成AMRSR任务的患者，基于Fast-VEctor的时空分析可以建立准确和可靠的Broca和Wernicke区定位，并确定半球优势。对于听觉功能正常的受试者，AMRSR范式评估显示出显着的承诺，提供可靠的评估大脑语言优势和语言网络定位。
The study aims to (1) examine the spatiotemporal map of magnetoencephalography-evoked responses during an Auditory Memory Retrieval and Silent Repeating (AMRSR) task, and determine the hemispheric dominance for language, and (2) evaluate the accuracy of the AMRSR task in Wernicke and Broca area localization. In 30 patients with brain tumors and/or epilepsies, the AMRSR task was used to evoke magnetoencephalography responses. We applied Fast VEctor-based Spatial–Temporal Analyses with minimum L1-norm source imaging method to the magnetoencephalography responses for localizing the brain areas evoked by the AMRSR task. The Fast-VEctor-based Spatial–Temporal Analysis found consistent activation in the posterior superior temporal gyrus around 300 to 500 ms, and another activation in the frontal cortex (pars opercularis and/or pars triangularis) around 600 to 900 ms, which were localized to the Wernicke area (BA 22) and Broca area (BA 44 and BA 45), respectively. The language-dominant hemispheric laterization elicited by the AMRSR task was comparable with the result from an Auditory Dichotic task result given to the same patient, with the exception that AMRSR is more sensitive on bilateral language laterization cases on finding the Wernicke and Broca areas. For all patients who successfully finished the AMRSR task, Fast-VEctor-based Spatial–Temporal Analysis could establish accurate and robust localizations of Broca and Wernicke area and determine hemispheric dominance. For subjects with normal auditory functionality, the AMRSR paradigm evaluation showed significant promise in providing reliable assessments of cerebral language dominance and language network localization.
影响因子：
5.7
作者：
Huang MX;Huang CW;Robb A;Angeles A;Nichols SL;Baker DG;Song T;Harrington DL;Theilmann RJ;Srinivasan R;Heister D;Diwakar M;Canive JM;Edgar JC;Chen YH;Ji Z;Shen M;El-Gabalawy F;Levy M;McLay R;Webb-Murphy J;Liu TT;Drake A;Lee RR
通讯作者：
Lee RR