Peroxiredoxin 2 as a chemotherapy responsiveness biomarker candidate in osteosarcoma revealed by proteomics
Peroxiredoxin 2 as a chemotherapy responsiveness biomarker candidate in osteosarcoma revealed by proteomics
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DOI：
10.1002/prca.200900172
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发表时间：
2010-05-01
影响因子：
2
通讯作者：
Kondo, Tadashi
中科院分区：
文献类型：
--
作者：
Kikuta, Kazutaka;Tochigi, Naobumi;Kondo, Tadashi
目的：我们的目的是确定新的化疗反应性生物标志物骨肉瘤（OS）通过调查的全球蛋白质表达谱的12个活检标本从OS patients.Experimental design：6例患者被归类为良好的反应者和6个反应不良，根据Huvos分级系统。结果：共鉴定出55个蛋白质点，其蛋白质表达强度差异显著（Bonferroni校正的p值
Purpose: We aimed to identify novel chemotherapy responsiveness biomarkers for osteosarcoma (OS) by investigating the global protein expression profile of 12 biopsy samples from OS patients.Experimental design: Six patients were classified as good responders and six as poor responders, according to the Huvos grading system. The protein expression profiles obtained by 2-D DIGE consisted of 2250 protein spots.Results: Among them, we identified 55 protein spots whose intensity was significantly different (Bonferroni adjusted p-value