ROLE OF ANTIBODY TO S100 PROTEIN IN DIAGNOSTIC PATHOLOGY
ROLE OF ANTIBODY TO S100 PROTEIN IN DIAGNOSTIC PATHOLOGY
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DOI：
10.1093/ajcp/79.3.341
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发表时间：
1983-01-01
影响因子：
3.5
通讯作者：
BAUMAL, R
中科院分区：
文献类型：
--
作者：
KAHN, HJ;MARKS, A;BAUMAL, R
在免疫过氧化物酶反应中，使用抗S100蛋白抗血清检测正常[人]组织和各种肿瘤的S100蛋白。在正常组织中，除了先前报道的在一些神经元、神经系统的神经胶质细胞和雪旺细胞、皮肤的黑素细胞和朗格汉斯细胞、淋巴结的交错网状细胞和软骨细胞中存在S100蛋白外，还在汗腺、唾液腺和乳腺的肌上皮细胞和导管、肺的浆液腺、胎儿成神经细胞和肾上腺髓质的支持细胞。在肿瘤中，S100蛋白已在神经源性肿瘤、黑色素瘤和神经母细胞瘤中报道;在混合性汗腺肿瘤、组织细胞增生症X、唾液腺多形性腺瘤、乳腺髓样癌、肺细支气管肺泡癌、嗜铬细胞瘤的支持细胞、卵巢畸胎瘤和软骨肿瘤（内生软骨瘤、骨软骨瘤和软骨肉瘤）中得到证实。在产生S100蛋白的肿瘤中，鉴定出正常祖细胞，表明肿瘤中S100蛋白的证明证实了它们的起源。
Normal [human] tissues and various tumors were examined for S100 protein, using anti-S100 protein antiserum, in an immunoperoxidase reaction. Among normal tissues, in addition to the previously reported presence of S100 protein in some neurons, glial and Schwann cells of the nervous system, melanocytes and Langerhans cells of the skin, interdigitating reticulum cells of lymph nodes, and chondrocytes, it was demonstrated in myoepithelial cells and ducts of sweat glands, salivary glands and the breast, serous glands of the lung, fetal neuroblasts and sustentacular cells of the adrenal medulla. Among neoplasms, S100 protein has been reported in neurogenic tumors, melanomas and neuroblastomas; it was demonstrated in mixed sweat gland tumors, histiocytosis X, pleomomorphic adenomas of the salivary gland, medullary carcinomas of the breast, bronchioloalveolar carcinomas of the lung, sustentacular cells of pheochromocytomas, teratomas of the ovary and tumors of cartilage (enchondromas, osteochondromas and condrosarcomas). With S100 protein producing tumors, a normal progenitor cell was identified, indicating that demonstration of S100 protein in tumors confirmed their origin.