Neurotensin: Central nervous system effects of a hypothalamic peptide
Neurotensin: Central nervous system effects of a hypothalamic peptide
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神经降压素：下丘脑肽的中枢神经系统作用
DOI：
10.1016/0006-8993(77)90173-1
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发表时间：
1977
期刊：
影响因子：
2.9
通讯作者：
M. Lipton
中科院分区：
文献类型：
--
作者：
C. Nemeroff;G. Bissette;A. Prange;P. Loosen;T. Barlow;M. Lipton
在25 °C的环境温度下，神经降压素（一种内源性下丘脑十三肽）的中枢给药使小鼠和大鼠的体温显著降低，并与剂量相关。当将小鼠置于4°C以增加体温下降速度时，这种效果更加明显。在中枢给予神经降压素后观察到的其他后遗症是大鼠自发活动的减少和戊巴比妥诱导的死亡率、镇静和体温过低的明显剂量相关性增强。后一种效应被证明是由于巴比妥酸盐的代谢降解显著减少。在外周神经降压素给药后没有观察到上述作用，表明该肽不容易穿过血脑屏障。神经降压素似乎是一个不断增长的名单，可以影响中枢神经系统功能的神经肽。
The central administration of neurotensin, an endogenous hypothalamic tridecapeptide, produces a marked dose-related decrease in body temperature of mice and rats at an ambient temperature of 25 °C. This effect is even more pronounced when mice are placed at 4°C to increase the rate of decline of body temperature. Other sequelae observed after central administration of neurotensin are decreases in locomotor activity in rats and a marked dose-related enhancement in pentobarbital-induced mortality, sedation and hypothermia. This latter effect was shown to be due to a significant reduction in the metabolic degradation of the barbiturate. None of the above-mentioned effects are observed after peripheral neurotensin administration, suggesting that this peptide does not readily cross the blood-brain barrier. Neurotensin appears to be one of a growing list of neuropeptides that can affect CNS function.