LIPOGRANULOMAS IN NON-FATTY HUMAN LIVERS - A MINERAL-OIL INDUCED ENVIRONMENTAL DISEASE
LIPOGRANULOMAS IN NON-FATTY HUMAN LIVERS - A MINERAL-OIL INDUCED ENVIRONMENTAL DISEASE
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DOI：
10.1093/ajcp/78.1.35
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发表时间：
1982-01-01
影响因子：
3.5
通讯作者：
MACGEE, J
中科院分区：
文献类型：
--
作者：
DINCSOY, HP;WEESNER, RE;MACGEE, J
本文报告44例非脂肪肝（NFL）脂肪肉芽肿（LG），包括38例活检和6例尸检。NFL中的LG具有明显的形态特征，几乎全部与肝小静脉壁相连或紧密相连。这个特殊位置的原因仍然无法解释。从脂质组织化学和分析的脂质提取物的肝脏和食品的TLC和GLC的数据表明，LG在NFL最有可能代表的反应，吸收饱和烃类，如矿物油，广泛用于食品工业。LG的发病率有所增加，1952-1953年的发病率为1.7%，而1978-1980年为4.6%。只要连续切片检查，LG很少出现诊断问题。了解特征性形态学可防止广泛的肉芽肿检查。它们似乎是肝活检的偶然发现，目前没有临床意义;它们的长期影响，如果有的话，必须等待未来的观察。
Cases (44) of lipogranulomas (LG) in nonfatty livers (NFL), consisting of 38 biopsies and 6 autopsy livers, were studied. LG in NFL had a distinct morphologic characteristic and virtually all were attached to or closely associated with the walls of hepatic venules. The reason for this peculiar location remained unexplained. Data from lipid histochemistry and analysis of lipid extracts from the livers and foodstuffs by TLC and GLC indicated that LG in NFL most likely represented a reaction to absorbed saturated hydrocarbons, like mineral oil, used widely in the food industry. The incidence of LG has increased, as evidenced by a 1.7% incidence in 1952-1953 compared with 4.6% in 1978-1980. LG seldom present a diagnostic problem provided serial sections are examined. An awareness of the characteristic morphology will prevent an extensive granuloma work-up. They appear to be an incidental finding in liver biopsies and of no clinical significance at present; their long-term implication, if any, must await future observations.