Long-term weight regain after gastric bypass: A 5-year prospective study
Long-term weight regain after gastric bypass: A 5-year prospective study
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DOI：
10.1007/s11695-007-9265-1
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发表时间：
2008-06-01
期刊：
影响因子：
2.9
通讯作者：
Pareja, Jose Carlos
中科院分区：
文献类型：
--
作者：
Magro, Daniela Oliveira;Geloneze, Bruno;Pareja, Jose Carlos
背景：肥胖手术后体重会增加，而通常在手术后18至24个月观察到体重较低。本研究的目的是评估在5年的随访period.Materials和方法的纵向前瞻性研究782肥胖患者的性别提交胃旁路术的患者体重恢复。仅纳入至少2年手术的患者。将术后24、36、48和60个月的超重体重指数（BMI）下降百分比与术后18个月的测量值进行比较。结果术后18个月BMI下降百分比显著高于术后12个月（p < 0.001），术后12个月与术后18个月相比，BMI平均差异为1.06kg/m2。24个月后BMI下降百分比不再显著，术后48个月内体重恢复显著（p < 0.01）。在出现体重恢复的患者中，与术后18个月获得的最低体重相比，在60个月内观察到平均8%的增加。手术失败的比例较高，在超肥胖组在所有时间的研究，达到18.8%，在48个月后surgery.Conclusion体重恢复观察手术后24个月内约50%的患者。超肥胖组的体重恢复和手术失败率都更高。关于体重恢复的代谢和激素机制的研究可能会阐明这一发现的原因。
Background A certain weight gain occurs after obesity surgery compared to the lower weight usually observed between 18 and 24 months postsurgery. The objective of this study was to evaluate weight regain in patients submitted to gastric bypass over a 5-year follow-up period.Materials and Methods A longitudinal prospective study was conducted on 782 obese patients of both genders. Only patients with at least 2 years of surgery were included. The percentage of excess body mass index (BMI) loss at 24, 36, 48, and 60 months postsurgery was compared to the measurements obtained at 18 months after surgery. Surgical therapeutic failure was also evaluated.Results Percent excess BMI loss was significant up to 18 months postsurgery (p < 0.001), with a mean difference in BMI of 1.06 kg/m(2) compared to 12 months postsurgery. Percent BMI loss was no longer significant after 24 months, and weight regain became significant within 48 months after surgery (p < 0.01). Among the patients who presented weight regain, a mean 8% increase was observed within 60 months compared to the lowest weight obtained at 18 months after surgery. The percentage of surgical failure was higher in the superobese group at all times studied, reaching 18.8% at 48 months after surgery.Conclusion Weight regain was observed within 24 months after surgery in approximately 50% of patients. Both weight regain and surgical failure were higher in the superobese group. Studies in regard to metabolic and hormonal mechanisms underlying weight regain might elucidate the causes of this finding.