Delayed shrinkage of the brain after ischemic stroke: Preliminary observations with voxel-guided morphometry
Delayed shrinkage of the brain after ischemic stroke: Preliminary observations with voxel-guided morphometry
复制标题
DOI：
10.1177/1051228404264950
复制
发表时间：
2004-07-01
影响因子：
2.4
通讯作者：
Seitz, DJ
中科院分区：
文献类型：
--
作者：
Kraemer, M;Schormann, T;Seitz, DJ
背景和目的。脑缺血最重要的影响是脑梗死。在这项磁共振成像（MRI）研究中，作者旨在评估缺血后脑萎缩。方法.回顾性研究了10例首次急性大脑中动脉缺血的患者。在急性和慢性梗死后记录三维MRI容积扫描，并使用新开发的体素引导形态测量学逐体素分析。结果在所有患者中均检测到脑组织收缩，不仅在病灶周围皮质结构中，而且在对侧同源皮质区和纹状体和丘脑的皮质下。这种二次收缩与梗死面积或患者的临床结果无关。结论.我们的研究表明，急性缺血性卒中后迟发性脑萎缩涉及与缺血性脑损伤解剖学相关的区域，但同时伴有神经功能缺损的改善。
Background and Purpose. The most important effect of cerebral ischemia is brain infarction. In this magnetic resonance imaging (MRI) study, the authors aimed at assessing postischemic brain atrophy. Methods. Ten patients suffering from their first acute cerebral ischemia in the territory of the middle cerebral artery were studied retrospectively. Three-dimensional MRI volume scans were recorded in the acute and chronic stage after infarction and analyzed voxel by voxel intraindividually with the newly developed voxel-guided morphometry. Results. Shrinkage of brain tissue was detected in all patients, not only in the perilesional cortical structures but also in contralateral homolog cortex areas and subcortically in the striatum and thalamus. This secondary shrinkage was not related to the size of the infarcts or to the clinical outcome of patients. Conclusions. Our study suggests that delayed brain atrophy after acute ischemic stroke involved areas anatomically connected with the ischemic brain lesion but nevertheless was accompanied by a simultaneous improvement of the neurological deficit.