Modelling chemotherapy resistance in palliation and failed cure
Modelling chemotherapy resistance in palliation and failed cure
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DOI：
10.1016/j.jtbi.2008.12.006
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发表时间：
2009-03-21
影响因子：
2
通讯作者：
Gaffney, Eamonn A.
中科院分区：
文献类型：
--
作者：
Monro, Helen C.;Gaffney, Eamonn A.
姑息性癌症化疗治疗的目标是在肿瘤根除不可行时延长生存期并提高生活质量。化疗方案设计被认为是在这种情况下，使用一个简单的，强大的，先进的投票率增长模型Gompertzian动力学，考虑到耐药性的影响。据预测，减少化疗方案可以很容易地导致改善的生存时间，由于耐药和敏感的投票细胞之间的竞争的影响。非常早期的姑息也预计很快产生近总道岔电阻，从而减少生存时间。最后，我们的模拟表明，失败的治疗尝试使用剂量致密化，一个共同的协议升级策略，可以减少生存时间。(C)2009爱思唯尔有限公司保留所有权利。
The goal of palliative cancer chemotherapy treatment is to prolong survival and improve quality of life when tumour eradication is not feasible. Chemotherapy protocol design is considered in this context using a simple, robust, model of advanced turnout growth with Gompertzian dynamics, taking into account the effects of drug resistance. It is predicted that reduced chemotherapy protocols can readily lead to improved survival times due to the effects of competition between resistant and sensitive turnout cells. Very early palliation is also predicted to quickly yield near total turnout resistance and thus decrease survival duration. Finally, our simulations indicate that failed curative attempts using dose densification, a common protocol escalation strategy, can reduce survival times. (C) 2009 Elsevier Ltd. All rights reserved.