Characteristics of Left Ventricular Receptors with Nonmedullated Vagal Afferents in Cats
Characteristics of Left Ventricular Receptors with Nonmedullated Vagal Afferents in Cats
复制标题
猫非髓性迷走神经传入左心室受体的特征
DOI：
10.1161/01.res.40.4.415
复制
发表时间：
1977
影响因子：
20.1
通讯作者：
P. Thoren
中科院分区：
文献类型：
--
作者：
P. Thoren
在麻醉开胸猫右颈迷走神经记录到来自非髓质传入的左心室受体的活动。心内直视探查发现，受体分布于游离壁和室间隔。来自后受体的纤维沿冠状动脉后降支和右心房外侧表面与右心主神经汇合；来自前外侧区域的纤维穿过主动脉和肺动脉干后方。对照受体放电为1.4(范围，0~6)次/秒，平均左室舒张末压(LVEDP)为4.5(范围，2~10)mm Hg。观察到受体释放随着输血或主动脉阻断产生的LVEDP的进行性增加而增加。在平均LVEDP为8 mm Hg时，平均放电频率为3.2个脉冲/秒，在16 mm Hg时，平均放电频率为7.0个脉冲/秒。研究还发现，心得安降低了LVEDP的放电频率，异丙肾上腺素增加了LVEDP的放电频率。总传导时间的测量表明，在LVEDP增加期间，受体主要在心脏周期的收缩部分被激活。尽管如此，放电频率和左心室收缩压之间没有明显的关系。
Activity from left ventricular receptors with nonmedullated afferents was recorded in the right cervical vagus in anesthetized, thoracotomized cats. Probing of the open heart demonstrated that the receptors were distributed throughout the free wall and the interventricular septum. Fibers from posterior receptors pass along the posterior descending coronary artery and the lateral surface of the right atrium to join the right main cardiac nerve; those from the anterolateral region pass behind the aorta and the pulmonary trunk. The control receptor discharge was 1.4 (range, 0–6) impulses/sec at a mean left ventricular end-diastolic pressure (LVEDP) of 4.5 (range, 2–10) mm Hg. It was observed that receptor discharge increased with progressive increase in LVEDP produced either by transfusion or by aortic occlusion. At a mean LVEDP of 8 mm Hg, the mean discharge rate was 3.2 impulses/sec, and at 16 mm Hg it was 7.0 impulses/sec. It was also found that propranolol reduced and isoproterenol increased the discharge frequency at any given LVEDP. Measurement of total conduction times indicated that during the increase in LVEDP the receptors were activated principally in the systolic portion of the cardiac cycle. Despite this there was no obvious relationship between the discharge frequency and left ventricular systolic pressure.