Cutaneous wart-associated HPV types: Prevalence and relation with patient characteristics
Cutaneous wart-associated HPV types: Prevalence and relation with patient characteristics
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DOI：
10.1016/j.jcv.2012.07.014
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发表时间：
2012-11-01
影响因子：
8.8
通讯作者：
Eekhof, Just A. H.
中科院分区：
文献类型：
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作者：
Bruggink, Sjoerd C.;de Koning, Maurits N. C.;Eekhof, Just A. H.
背景资料：皮肤疣相关的HPV types的流行病学数据是罕见的。Objective. To研究皮肤疣相关的HPV类型的患病率及其与patient characteristics.Study design：拭子取自所有744疣的246个连续的免疫功能正常的参与者，并通过广谱HSL-PCR/MPG检测分析。患者的详细信息，包括位置，持续时间和疣的数量recorded.Results：49（7%）拭子中未检测到HPV DNA，577（78%）拭子中的单一HPV类型，118（16%）拭子中的多种HPV类型。HPV 2、27、57（α属）、HPV 4（γ属）和HPV 1（μ属）是最常见的HPV类型，HPV 63（μ属）仅与其他HPV类型一起常见。较不常见的HPV类型是HPV 3、7、10和28（α属），65、88和95（γ属）和41（nu属）。含有HPV 1的疣显示出最独特的临床特征，
Background: Epidemiological data on cutaneous wart-associated HPV types are rare.Objectives: To examine the prevalence of cutaneous wart-associated HPV types and their relation with patient characteristics.Study design: Swabs were taken from all 744 warts of 246 consecutive immunocompetent participants and analysed by a broad spectrum HSL-PCR/MPG assay. Patient details including location, duration, and number of warts were recorded.Results: No HPV DNA was detected in 49 (7%) swabs, a single HPV type in 577 (78%) swabs, and multiple HPV types in 118 (16%) swabs. HPV 2, 27 and 57 (alpha genus), HPV 4 (gamma genus) and HPV 1 (mu genus) were the most frequently detected HPV types, and HPV 63 (mu genus) was only frequently detected together with other HPV types. Less frequently detected HPV types were HPV 3, 7, 10 and 28 (alpha genus), 65, 88 and 95 (gamma genus) and 41 (nu genus). Warts containing HPV 1 showed the most distinct clinical profile, being related to children aged