The tissue diagnostic instrument
The tissue diagnostic instrument
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DOI：
10.1063/1.3127602
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发表时间：
2009-05-01
影响因子：
1.6
通讯作者：
Lotz, Jeffrey
中科院分区：
文献类型：
--
作者：
Hansma, Paul;Yu, Hongmei;Lotz, Jeffrey
组织机械性能反映了细胞外基质的组成和组织，因此，它们的变化可能是疾病的标志。此类疾病的实例包括椎间盘变性、癌症、动脉粥样硬化、骨关节炎、骨质疏松症和蛀牙。在这里，我们介绍了组织诊断仪（TDI），一种旨在探测正常和患病的软组织和硬组织的力学性能，不仅在实验室，而且在病人的设备。TDI可以区分椎间盘的核和环，年轻和退化的软骨，以及正常和癌变的乳腺。它可以量化的弹性模量和硬度的湿牙本质后，在洞挖。它可以执行骨组织的压痕测试，量化压痕深度增加和其他机械参数。使用局部麻醉和一次性无菌探头组件，在对患者进行测试时既没有疼痛也没有并发症。我们预计，这种独特的设备将促进对生物体（包括植物）中许多组织系统的研究，从而对疾病机制和早期检测方法产生新的见解。
Tissue mechanical properties reflect extracellular matrix composition and organization, and as such, their changes can be a signature of disease. Examples of such diseases include intervertebral disk degeneration, cancer, atherosclerosis, osteoarthritis, osteoporosis, and tooth decay. Here we introduce the tissue diagnostic instrument (TDI), a device designed to probe the mechanical properties of normal and diseased soft and hard tissues not only in the laboratory but also in patients. The TDI can distinguish between the nucleus and the annulus of spinal disks, between young and degenerated cartilage, and between normal and cancerous mammary glands. It can quantify the elastic modulus and hardness of the wet dentin left in a cavity after excavation. It can perform an indentation test of bone tissue, quantifying the indentation depth increase and other mechanical parameters. With local anesthesia and disposable, sterile, probe assemblies, there has been neither pain nor complications in tests on patients. We anticipate that this unique device will facilitate research on many tissue systems in living organisms, including plants, leading to new insights into disease mechanisms and methods for their early detection.