AUTOREGULATION OF BEAT FREQUENCY IN RESPIRATORY CILIATED CELLS - DEMONSTRATION BY VISCOUS LOADING
AUTOREGULATION OF BEAT FREQUENCY IN RESPIRATORY CILIATED CELLS - DEMONSTRATION BY VISCOUS LOADING
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DOI：
10.1164/ajrccm/144.5.1091
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发表时间：
1991-11-01
期刊：
影响因子：
--
通讯作者：
VERDUGO, P
中科院分区：
文献类型：
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作者：
JOHNSON, NT;VILLALON, M;VERDUGO, P
与水施加在纤毛虫纤毛上的几乎恒定的载荷不同，呼吸纤毛上的流体动力载荷可以由于粘液流变性的变化而发生很大的变化。当水上纤毛细胞暴露在粘度增加(1-50cP)时，它们的拍频呈指数下降。根据牛顿的流体动力学理论，对于产生恒定力的发动机来说，这一结果是预期的。然而，本文报道的结果表明，当粘液推进的呼吸纤毛细胞暴露在从12到150CP的高粘性负荷下时，纤毛搏动的频率仅略有下降，而搏动幅度几乎保持不变。这些观察表明，呼吸道纤毛细胞具有功能储备，使它们能够自动调节其机械输出，以应对它们通常暴露在呼吸道中的粘度变化。
As opposed to the virtually constant load exerted by water on the cilia of ciliated protozoa, the hydrodynamic load on respiratory cilia can undergo broad variations because of changes in the rheologic properties of mucus. When water-rowing ciliated cells are exposed to increased viscosity (1 to 50 cP), their beat frequency decreases exponentially. According to Newton's fluid dynamic theory, this outcome is expected for an engine that generates constant force. However, the findings reported here indicate that when mucus-propelling respiratory ciliated cells are exposed to high viscous loads, ranging from 12 to 150 cP, the frequency of ciliary beat decreases only slightly, whereas the beat amplitude remains virtually constant. These observations suggest that ciliated cells of the respiratory tract have a functional reserve that allows them to autoregulate their mechanical output in response to the changes in viscosity to which they are normally exposed in the airway.