An antibody that prevents the hemagglutinin low pH fusogenic transition
An antibody that prevents the hemagglutinin low pH fusogenic transition
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DOI：
10.1006/viro.2001.1320
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发表时间：
2002-03-01
期刊：
影响因子：
3.7
通讯作者：
Knossow, M
中科院分区：
文献类型：
--
作者：
Barbey-Martin, C;Gigant, B;Knossow, M
We have determined the structure of a complex of influenza hemagglutinin (HA) with an antibody that binds simultaneously to the membrane-distal domains of two HA monomers, effectively cross-linking them. The antibody prevents the low pH structural transition of HA that is required for its membrane fusion activity, providing evidence that a rearrangement of HA membrane-distal domains is an essential component of the transition. (C) 2002 Elsevier Science (USA).
