3D multivoxel proton spectroscopy of human brain using a hybrid of 8th-order Hadamard encoding with 2D chemical shift imaging
3D multivoxel proton spectroscopy of human brain using a hybrid of 8th-order Hadamard encoding with 2D chemical shift imaging
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DOI：
10.1002/mrm.1910390108
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发表时间：
1998-01-01
影响因子：
3.3
通讯作者：
Goelman, G
中科院分区：
文献类型：
--
作者：
Gonen, O;Murdoch, JB;Goelman, G
利用一维8阶横向阿达玛德光谱成像（HSI）和二维化学位移成像（CSI）的混合技术，在人脑中展示了多体素三维定位质子光谱。空间选择性HSI脉冲自然结合到PRESS序列中（TE = 135 ms），然后激发8 x 8 x 6 cm平行六面体感兴趣体积（VOI）并将其细分为8个切片。使用2D CSI将这些切片的平面进一步划分为16 × 16体素阵列，从而在VOI内产生8 × 8 × 8体素。同时3D覆盖从这些0.75 ml体素中产生良好的体素信噪比（胆碱、肌酸和n -乙酰天冬氨酸分别为8、12和22），大约需要45分钟。高度的空间隔离使得定位在距离头骨不到1厘米的范围内，没有脂肪污染。
Multivoxel 3D localized proton spectroscopy using a hybrid of 1D 8th-order transverse Hadamard spectroscopic imaging (HSI) with 2D chemical shift imaging (CSI) is demonstrated in human brain. The spatially selective HSI pulse incorporates naturally into the PRESS sequence (TE = 135 ms), which then both excites an 8 x 8 x 6 cm parallelepiped volume of interest (VOI) and subdivides it into eight slices. The planes of these slices are further partitioned into 16 x 16 voxel arrays using 2D CSI to yield 8 x 8 x 8 voxels within the VOI. Simultaneous 3D coverage yields good voxel signal-to-noise (8, 12, and 22 for choline, creatine, and N-acetylaspartate, respectively) from these 0.75-ml voxels, in similar to 45 min. The high spatial isolation allows localization to within less than 1 cm from the skull without fat contamination.