Puerarin Improves Vascular Insulin Resistance and Cardiovascular Remodeling in Salt-Sensitive Hypertension
Puerarin Improves Vascular Insulin Resistance and Cardiovascular Remodeling in Salt-Sensitive Hypertension
复制标题
葛根素可改善盐敏感性高血压的血管胰岛素抵抗和心血管重塑。
DOI：
10.1142/s0192415x17500641
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发表时间：
2017-01-01
影响因子：
5.7
通讯作者：
Zhou, Ming-Sheng
中科院分区：
文献类型：
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作者：
Tan, Chunxiang;Wang, Aimei;Zhou, Ming-Sheng
葛根素是从中药葛根中提取的一种有效成分，在中医中广泛用于治疗高血压和糖尿病。Dahl盐敏感（DS）大鼠是一种具有心血管损伤和血管胰岛素抵抗的盐敏感性高血压遗传模型。在此，我们研究了葛根素是否改善了盐敏感性高血压患者的血管胰岛素抵抗，并减弱了心脏和主动脉重构。给DS大鼠喂正常（NS）或高盐饮食（HS）5周。另一组DS大鼠用葛根素和NS预处理10天，然后改用HS加葛根素5周。HS 5周可增加收缩压（SBP）、心肌肥厚、心肌纤维化和主动脉肥厚，并增加主动脉和心脏磷酸化ERK 1/2的表达;葛根素减弱心脏和主动脉肥大，高血压大鼠还表现出乙酰胆碱和胰岛素介导的血管舒张功能受损，胰岛素介导的血管舒张功能受损。介导的Akt和eNOS磷酸化与NF[分子式：见正文]B/TNF[分子式：见正文]/JNK途径的活化相关。葛根素通过抑制NF[分子式：见正文]B炎症通路改善乙酰胆碱和胰岛素介导的血管舒张和胰岛素刺激的Akt/NO信号传导。我们的研究结果表明，在盐敏感性高血压，葛根素改善血管胰岛素的作用与心血管有益的影响。本研究发现其作用机制可能与抑制NF[式：见正文]B/JNK和ERK 1/2通路有关。这些结果表明，葛根素可作为一种新的抗高血压药物，以扩大我们的医疗设备，用于预防和治疗终末器官损害的个人与高血压和代谢性疾病。
Puerarin is an isoflavonoid isolated from the Chinese herb, Kudzu roots (also known as Gegen), which has been widely used for the treatment of hypertensive diseases and diabetic mellitus in traditional Chinese medicine. Dahl salt-sensitive (DS) rat is a genetic model of salt-sensitive hypertension with cardiovascular injury and vascular insulin resistance. Here, we investigated whether puerarin improved vascular insulin resistance and attenuated cardiac and aortic remodeling in salt-sensitive hypertension. DS rats were given a normal (NS) or high salt diet (HS) for five weeks. An additional group of DS rats was pretreated with puerarin and NS for 10 days, then switched to HS plus puerarin for five weeks. HS for five weeks increased systolic blood pressure (SBP), cardiac hypertrophy and fibrosis, and aortic hypertrophy with increased the expression of phosphor-ERK1/2 in the aorta and heart; puerarin attenuated cardiac and aortic hypertrophy, cardiac fibrosis and phosphor-ERK1/2 with a mild reduction in SBP. Hypertensive rats also manifested impairment of acetylcholine- and insulin-mediated vasorelaxation and insulin-mediated Akt and eNOS phosphorylation associated with the activation of NF[Formula: see text]B/TNF[Formula: see text]/JNK pathway. Puerarin improved acetylcholine- and insulin-mediated vasorelaxation and insulin-stimulated Akt/NO signaling with the inhibition of the NF[Formula: see text]B inflammatory pathway. Our results demonstrated that in salt-sensitive hypertension, puerarin improved vascular insulin action with cardiovascular beneficial effects. Our results found that the underlying mechanisms may involve its inhibition of NF[Formula: see text]B/JNK and ERK1/2 pathway. These results suggest that puerarin could be used as a new antihypertensive agent to expand our armamentarium for the prevention and treatment of end-organ damage in individuals with hypertension and metabolic diseases.