Reaction of 3/2-formylindoles with TOSMIC: formation of indolyloxazoles and stable indolyl primary enamines
Reaction of 3/2-formylindoles with TOSMIC: formation of indolyloxazoles and stable indolyl primary enamines
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DOI：
10.1016/j.tet.2004.12.022
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发表时间：
2005-02-14
期刊：
影响因子：
2.1
通讯作者：
Takayanagi, H
中科院分区：
文献类型：
--
作者：
Chakrabarty, M;Basak, R;Takayanagi, H
3-芳基吲哚及其 1-取代和 1,5-二取代衍生物与 TOSMIC 在碳酸钾存在下在甲醇中回流反应，得到 5-(3'-吲哚基)恶唑、新的稳定 E-2-(3'-吲哚基)-2-甲苯磺胺和 N-[2-(3'-吲哚基)-1,2-二甲氧基]乙基甲酰胺的两种非对映异构体。相反，2-甲酰粪臭素提供N-(1-甲苯磺酰基-2-粪臭素基)乙烯基甲酰胺。 (C) 2004 Elsevier Ltd. 保留所有权利。
3-Fonnylindole and its 1-substituted and 1,5-disubstituted derivatives react with TOSMIC in presence of potassium carbonate in methanol under reflux to furnish 5-(3'-indolyl)oxazoles, new stable E-2-(3'-indolyl)-2-tosylethenamines and two diastereomers of N-[2-(3'-indolyl)- 1,2-dimethoxy]ethylformamides. In contrast, 2-formylskatole furnishes N-(1-tosyl-2-skatolyl)ethenylformamide. (C) 2004 Elsevier Ltd. All rights reserved.