A simple introduction to pharmacokinetics: Part 1

A simple introduction to pharmacokinetics: Part 1
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药代动力学简单介绍:第 1 部分

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发表时间:
2014
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通讯作者:
G. Hughes
G. Hughes
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文献类型:
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作者:
G. Hughes

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“为什么是片剂,为什么是在进食前?”“为什么这不是一种合适的药物--我的病人和你的情况一样?”或者‘为什么不能同时开这些药?’这些都是你可能在某个时候问过的问题。答案从根本上取决于对药物动力学的理解,或者说简单地说,就是身体对药物的反应。了解药代动力学的基本原理可以是简单的,也可以是复杂的(想想方程式、计算和数学模型)。这个由两部分组成的系列文章的第一部分侧重于前者,目的是提供影响药物吸收和分配的主要因素和考虑因素的基本、朴实无华的概述,并帮助指导您找到“为什么”的答案。
‘Why in tablet form and why before food?,’ ‘Why is this not a suitable drug–my patient has the same condition as yours?’ or ‘Why can't these be prescribed together?’ are questions you might have asked at one point. The answers fundamentally rely on an understanding of pharmacokinetics, or simply, what the body does to drugs. Appreciating the underlying principles of pharmacokinetics can be simple or complex (think equations, calculations and mathematical models). The first part of this two-part series focuses on the former with an aim to provide a basic, ‘no-frills’ overview of the main factors and considerations influencing the absorption and distribution of drugs and to help guide you towards answers for the ‘Whys’.