Maternal 25-hydroxyvitamin D concentration and offspring birth size: effect modification by infant VDR genotype
Maternal 25-hydroxyvitamin D concentration and offspring birth size: effect modification by infant VDR genotype
复制标题
DOI：
10.1038/ejcn.2008.55
复制
发表时间：
2009-06-01
影响因子：
4.7
通讯作者：
Ponsonby, A-L
中科院分区：
文献类型：
--
作者：
Morley, R.;Carlin, J. B.;Ponsonby, A-L
背景/目的：我们检验了母体25-羟基维生素D （25-(OH)D）与子代出生尺寸之间关系的假设，根据子代维生素D受体（VDR）基因型（Apa1、Bsm1、Fok1或Taq1）的不同而不同。对象/方法：354名单胎婴儿的母亲在妊娠28-30周时测定血清25-(OH) D浓度，并同意在婴儿出生后不久对其进行测定。从婴儿的格思里卡片中提取了DNA。结果：有证据表明，婴儿福氏菌基因型改变了疗效。FF或FF基因型的缺陷母亲的婴儿出生体重较低，但FF基因型的婴儿出生体重较低（调整潜在混杂因素后的相互作用P值= 0.02）；FF基因型的婴儿肩胛下和髌上皮肤皱褶较厚，但FF基因型的婴儿出生体重较厚（P = 0.008和0.02）。样本量不足以研究其他VDR多态性对效果的影响。结论：这些初步发现表明，对母亲维生素D状态和出生尺寸的研究可能需要考虑VDR基因型。欧洲临床营养学杂志（2009）63,802 -804；doi: 10.1038 / ejcn.2008.55;2008年11月19日在线发布
Background/Objectives: We tested the hypothesis that the relationship between maternal 25-hydroxyvitamin D (25-(OH)D) and offspring birth size differs according to offspring vitamin D receptor (VDR) genotype (Apa1, Bsm1, Fok1 or Taq1).Subjects/Methods: Mothers of 354 singleton babies had serum 25-(OH) D concentration measured at 28-30 weeks of gestation and consented to measurement of their babies soon after birth. DNA was extracted from the babies' Guthrie cards.Results: There was evidence of effect modification by infant FokI genotype. Babies of deficient mothers had lower birth weight with FF or Ff, but not ff genotype (P-value for interaction after adjustment for potential confounding factors = 0.02), but thicker subscapular and suprailiac skinfolds with ff, but not FF or Ff genotype (P = 0.008 and 0.02, respectively). Sample size was insufficient to investigate effect modification by the other VDR polymorphisms.Conclusions: These preliminary findings suggest that studies of maternal vitamin D status and birth size may need to take VDR genotype into account. European Journal of Clinical Nutrition (2009) 63, 802-804; doi:10.1038/ejcn.2008.55; published online 19 November 2008