Methamphetamine-induced toxicity: an updated review on issues related to hyperthermia.
Methamphetamine-induced toxicity: an updated review on issues related to hyperthermia.
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DOI：
10.1016/j.pharmthera.2014.05.001
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发表时间：
2014-10
影响因子：
13.5
通讯作者：
O'Callaghan JP
中科院分区：
文献类型：
--
作者：
Matsumoto RR;Seminerio MJ;Turner RC;Robson MJ;Nguyen L;Miller DB;O'Callaghan JP
与甲基苯丙胺相关的急诊室就诊报告表明，体温升高是一种普遍的表现症状，致命的过量通常与极端体温过高有关。这篇综述总结了有关甲基苯丙胺毒性的现有信息，因为它涉及到体温升高。首先，简要概述了体温调节机制。接下来，已被认为是潜在的参与甲基苯丙胺高热的中央和外周目标进行了讨论。最后，提出了未来的调查领域，需要进一步的研究，以提供更深入的机制，介导的甲基苯丙胺引起的体温变化。
Reports of methamphetamine-related emergency room visits suggest that elevated body temperature is a universal presenting symptom, with lethal overdoses generally associated with extreme hyperthermia. This review summarizes the available information on methamphetamine toxicity as it pertains to elevations in body temperature. First, a brief overview of thermoregulatory mechanisms is presented. Next, central and peripheral targets that have been considered for potential involvement in methamphetamine hyperthermia are discussed. Finally, future areas of investigation are proposed, as further studies are needed to provide greater insight into the mechanisms that mediate the alterations in body temperature elicited by methamphetamine.