Estrogen treatment induces elevated expression of HMG1 in MCF-7 cells
Estrogen treatment induces elevated expression of HMG1 in MCF-7 cells
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DOI：
10.1006/excr.1998.4052
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发表时间：
1998-05-25
影响因子：
3.7
通讯作者：
Lee, KLD
中科院分区：
文献类型：
--
作者：
Chau, KY;Lam, HYP;Lee, KLD
高迁移率族蛋白1（HMG 1）是一种高度保守的染色体蛋白，广泛存在于活跃的染色质中。本研究观察了雌激素对人高迁移率族蛋白HMG 1基因表达的影响，发现雌激素处理MCF-7细胞30 min后，HMG 1 mRNA水平急剧增加2.5倍。在连续雌激素处理下，HMG 1 mRNA水平在90 min时降至基础水平的1.5倍，并在雌激素处理下保持在此升高的水平长达24 h。这些结果支持了Verrier等人（C. S. Verrier，1997，Mel. Endocrinol，11，1009-1019），HMG 1促进雌激素受体与雌激素反应元件的结合，并进一步加强了我们的信念，即HMG 1在雌激素诱导的基因表达中起重要作用。(C)北京：科学出版社.
The high mobility group (HMG)1 protein is a highly conserved and ubiquitous chromosomal protein found enriched in active chromatin, In this study, we have investigated the effect of estrogen on the expression of the human high mobility group protein HMG1 gene and found that the HMG1 mRNA level in MCF-7 cells was sharply increased 2.5-fold after 30 min of estrogen treatment. Under continuous estrogen treatment, the HMG1 mRNA level decreased to a 1.5 times that of the basal level at 90 min and remained at this elevated level under estrogen treatment for up to 24 h. These results support the recent finding by Verrier et al, (C. S. Verrier, 1997, Mel. Endocrinol, 11, 1009-1019) that HMG1 promotes the binding of the estrogen receptor to the estrogen response element and further reinforce our believe that HMG1 plays a significant role in estrogen-induced gene expression. (C) 1998 Academic Press.