Expression of the interleukin-2 receptor α (CD25) is selectively decreased on decidual CD4+ and CD8+ T lymphocytes in normal pregnancies
Expression of the interleukin-2 receptor α (CD25) is selectively decreased on decidual CD4+ and CD8+ T lymphocytes in normal pregnancies
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DOI：
10.1093/molehr/8.7.667
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发表时间：
2002-07-01
影响因子：
4
通讯作者：
Ho, HN
中科院分区：
文献类型：
--
作者：
Chao, KH;Wu, MY;Ho, HN
在之前的研究中，我们证明，与外周血相比，黄体期后和整个妊娠早期子宫内膜和蜕膜中活化的T细胞（CD69（+）CD3（+）和HLA-DR+ CD3（+））的比例较高。但子宫内膜和外周血中CD25(+)CD3(+)淋巴细胞的比例没有差异。本研究进一步证实正常妊娠时CD4(+)和CD8(+) T淋巴细胞上CD25的水平并未升高，但CD69和HLA-DR的水平明显升高。我们还阐明，与黄体期相比，妊娠期局部 T 淋巴细胞上所有三种激活分子的量均下调。然而，在核型正常和异常的无胚胎妊娠中，这些下降均显着减轻。然而，在外周血中，妊娠期激活分子水平的下调仅在CD4+细胞上表现出来，而HLA-DR在CD8+细胞上表现出下调。此外，双激活标记物分析表明，CD25 的表达似乎与同一蜕膜淋巴细胞上的 CD69 和 HLA-DR 分离。由于IL-2Rα在功能性T细胞的发育和增殖中发挥着关键作用，其表达降低可能导致母体对胎儿同种异体移植物的耐受性。
In a previous study, we demonstrated that the proportion of activated T cells (CD69(+) CD3(+) and HLA-DR+ CD3(+)) is higher in the endometrium and decidua after the luteal phase and throughout early pregnancy compared with in the peripheral blood. However, there was no difference in the proportion of CD25(+) CD3(+) lymphocytes between the endometrium and peripheral blood. In this study, we further verify that the levels of CD25 on CD4(+) and CD8(+) T lymphocytes are not increased in normal pregnancy, although the levels of CD69 and HLA-DR are markedly increased. We also elucidate that the amounts of all three activation molecules on local T lymphocytes are down-regulated in pregnancy compared with that during the luteal phase. Nevertheless, these decreases are significantly lessened in anembryonic pregnancies with both normal and abnormal karyotyping. However, in peripheral blood, the down-regulation of activation molecules levels in pregnancy is only demonstrated on CD4+ cells and for HLA-DR on CD8+ cells. Furthermore, dual activation marker analysis demonstrated that the expression of CD25 appears to be dissociated from CD69 and HLA-DR on the same decidual lymphocytes. Because IL-2Ralpha plays a pivotal role in the development and propagation of functional T cells, its depressed expression may result in maternal tolerance of the fetal allograft.