The Development of Retinal Function and Refractive Error in Children With Retinopathy of Prematurity.
The Development of Retinal Function and Refractive Error in Children With Retinopathy of Prematurity.
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DOI：
10.1167/iovs.64.11.35
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发表时间：
2023-08-01
影响因子：
4.4
通讯作者：
中科院分区：
文献类型：
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作者：
本研究的目的是检验早产儿视网膜病变（ROP）抑制视杆细胞介导的检测10度而非30度偏心刺激阈值的发展这一假设。此外，评价每个部位的阈值与视力（VA）和等效球镜（SE）的相关性。我们估计了前早产受试者（n = 111）中检测2度直径、50 ms、10度和30度偏心蓝光（λ < 510 nm）的视杆介导暗适应阈值（DAT），按ROP严重程度分层：无（n = 32）、轻度（n = 66）和重度（n = 13）。我们还测试了足月出生（n = 28）对照。为了确定每组的半数最大敏感性（半数）年龄和偏心率，我们将DAT拟合到逻辑生长曲线。我们获得了早产儿受试者的VA和SE，并评估了10度和30度时的阈值发展过程与10岁时预测的VA和SE的显著相关性。在ROP（轻度和重度）中，10度时DAT的发育显著延迟; ROP在30度时并未显著改变DAT的发育。在10岁时，在早产受试者中，VA和SE均与组（无、轻度和重度）显著相关。在30度时，通过DAT的发展过程预测SE。VA与10度DAT发展过程无关。在10度，ROP-无论是轻度或重度-与DAT发展的显着延迟有关，这表明晚熟的中央视网膜容易受到ROP的影响。30度阈值与近视的相关性证明了更多的周边视网膜对屈光发育是重要的。
The purpose of this study was to test the hypothesis that retinopathy of prematurity (ROP) prolongs development of rod-mediated thresholds for detection of stimuli at 10 degrees but not 30 degrees eccentricity. In addition, to evaluate the thresholds at each site for an association with visual acuity (VA) and spherical equivalent (SE). We estimated rod-mediated dark-adapted thresholds (DATs) for the detection of 2 degree diameter, 50 ms, blue (λ < 510 nm) flashes at 10 degrees and 30 degrees eccentric in former preterm subjects (n = 111), stratified by ROP severity: None (n = 32), Mild (n = 66), and Severe (n = 13). We also tested Term-born (n = 28) controls. To determine the age at half-maximal sensitivity (Agehalf) for each group and eccentricity, we fit DATs to logistic growth curves. We obtained VA and SE for Preterm subjects and evaluated the course of threshold development at 10 degrees and 30 degrees for significant association with VA and SE predicted at age 10 years. DAT development at 10 degrees was significantly delayed in ROP (Mild and Severe); ROP did not significantly alter DAT development at 30 degrees. At age 10 years, among Preterm subjects, both VA and SE were significantly associated with group (None, Mild, and Severe). SE was predicted by the course of DAT development at 30 degrees. VA was not associated with the course of DAT development at 10 degrees. At 10 degrees, ROP—whether mild or severe—is associated with significant delays in DAT development, evidence that the late-maturing central retina is vulnerable to ROP. The association of 30 degree threshold and myopia are evidence that more peripheral retina is important to refractive development.
影响因子：
4.2
作者：
Wiecek, Emily;Akula, James D.;Vanderveen, Deborah K.;Mantagos, Iason S.;Wu, Carolyn;Curran, Amber -Lee;De Bruyn, Hanna;Peterson, Bridget;Fulton, Anne B.
通讯作者：
Fulton, Anne B.