NMR Quantification of Halogen-Bonding Ability To Evaluate Catalyst Activity
NMR Quantification of Halogen-Bonding Ability To Evaluate Catalyst Activity
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DOI：
10.1021/acs.orglett.0c02427
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发表时间：
2020-08-21
期刊：
影响因子：
5.2
通讯作者：
Franz, Annaliese K.
中科院分区：
文献类型：
--
作者：
Chang, Yun-Pu;Tang, Teresa;Franz, Annaliese K.
描述了一系列苯并咪唑、咪唑和双咪唑（咪唑）卤素键给体（xbd）用P-31核磁共振光谱的能力。测量的δ δ (P-31)值与计算的活化能δ G（双匕首）和Friedel-Crafts吲哚加成的催化活性相关。该方法也可作为Bronsted酸杂质的灵敏指示剂。
Quantification of halogen-bonding abilities is described for a series of benzimidazolium-, imidazolium- and bis(imidazolium) halogen-bond donors (XBDs) using P-31 NMR spectroscopy. The measured Delta delta(P-31) values correlate with calculated activation free energy Delta G(double dagger) and catalytic activity for a Friedel-Crafts indole addition. This rapid method also serves as a sensitive indicator for Bronsted acid impurities.