Greater early weight gain and shorter breastfeeding are associated with low adolescent adiponectin levels.
Greater early weight gain and shorter breastfeeding are associated with low adolescent adiponectin levels.
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DOI：
10.1111/ijpo.12212
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发表时间：
2018-05
影响因子：
3.8
通讯作者：
Gahagan S
中科院分区：
文献类型：
--
作者：
Reyes M;Burrows R;Blanco E;Lozoff B;Gahagan S
Early life factors can program future risk for cardiovascular disease. We explored associations between adolescent adiponectin levels and concomitant metabolic alteration, and also looked at the association between early life factors and adolescent adiponectin levels. We studied a longitudinal cohort of low- to middle-income Chilean adolescents who were enrolled in an infancy iron deficiency anemia preventive trial and follow-up studies at the Institute of Nutrition and Food Technology, University of Chile, Santiago, Chile. In 577 adolescents who were assessed as part of the 16y follow-up, we evaluated independent associations between adiponectin levels and metabolic disturbances during adolescence. We also assessed the association between early life factors (short breastfeeding (˂6 months) and infancy weight gain) and adolescent adiponectin levels. Participants were 16.8 year-old (16.4–18.1), 48% female and 38% overweight/obese. Adolescent adiponectin levels were inversely associated with metabolic disturbances: altered homeostatic model assessment of insulin resistance and high-density lipoprotein cholesterol (ORs [95%CI]= 0.87 [0.79–0.95], p-value=0.002 and 0.90 [0.87–0.94], p-value<0.001, respectively), adjusting for sex and fat mass index. Early life factors were independently associated with adolescent adiponectin levels, which decreased 0.88 ug/mL per each unit increase in weight-for-age z-score between 0 and 6 months, and was 1.58 ug/mL lower among participants with short breastfeeding. Higher adolescent adiponectin levels were independently associated with lower odds of metabolic disturbances. Greater weight gain during infancy and shorter breastfeeding were associated with lower adolescent adiponectin levels, supporting research indicating early life as a window of opportunity for prevention of later cardiovascular alterations.
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