Behavioral rhythm and EEG rhythm to determine timing deficits in attention deficit hyperactivity disorder symptoms
Behavioral rhythm and EEG rhythm to determine timing deficits in attention deficit hyperactivity disorder symptoms
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行为节律和脑电图节律可确定注意力缺陷多动障碍症状的时间缺陷
DOI：
10.1016/j.heliyon.2020.e04546
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发表时间：
2020
期刊：
影响因子：
4
通讯作者：
Kawasaki Masahiro
中科院分区：
文献类型：
--
作者：
Kinumaki Shoko;Miyauchi Eri;Kawasaki Masahiro
注意力缺陷多动障碍（ADHD）的一个特征是时间缺陷，即难以敲击自己选择的步伐并保持步伐。据报道，时间障碍与额叶脑区有关。然而，用于评估这种时间缺陷的最佳方法以及伴随ADHD症状的相应神经机制尚未确定。为了解决这个问题，我们要求参与者按顺序敲击键盘的一个键，并保持他们敲击间隔的任意节奏。我们使用成人ADHD自我报告量表（ASRS）评估ADHD症状，并通过脑电图（EEG）评估大脑活动。行为学结果表明，高ASRS组表现出较大的叩击间隔间隙（定义为当前叩击间隔与上一次叩击间隔之间的时间差分布）。此外，EEG结果表明，高ASRS组中与工作负荷相关的脑活动（即额叶β活动）较高。这些结果表明，我们的任务和分析是有用的ADHD症状的评估，虽然它是初步的，由于样本量小，非病人的数据。
One characteristic of attention deficit hyperactivity disorder (ADHD) is a timing deficit, i.e. difficulty tapping a self-selected pace and keeping the pace. The timing disorder is reported to relate to the frontal brain area. However, optimal means for evaluating this timing deficit and the corresponding neural mechanisms that accompany ADHD symptoms have not been identified. To address the issue, we required participants to tap one key of a keyboard sequentially and to maintain arbitrary tempos of their tapping intervals. We assessed ADHD symptoms using the Adult ADHD Self-Report Scale (ASRS) and evaluated brain activity via electroencephalography (EEG). Behavioral results indicated that the high ASRS group displayed a large inter-tap-interval gap (defined as the distribution of the time difference between the current tapping interval and the last one). Moreover, EEG results indicated that the work-load related brain activity (i.e. frontal beta activity) was higher in the high ASRS group. These results suggest that our tasks and analyses are useful for the evaluation of ADHD symptoms, although it was preliminary due to the small sample size and the non-patient data.