High-frequency periodic sources underlie ventricular fibrillation in the isolated rabbit heart
High-frequency periodic sources underlie ventricular fibrillation in the isolated rabbit heart
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DOI：
10.1161/01.res.86.1.86
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发表时间：
2000-01-07
影响因子：
20.1
通讯作者：
Jalife, J
中科院分区：
文献类型：
--
作者：
Chen, J;Mandapati, R;Jalife, J
室颤（VF）的潜在机制尚不清楚。我们假设，至少有一些形式的VF不是随机的，并且高频周期性活动源表现为时空周期性，从而驱动VF。采用高分辨率视频成像结合心电图记录和频谱分析研究了8只Langendorff灌注兔心脏的24个VF事件。确定了以空间和时间周期性方式激活心室的顺序波前。此外，我们分析了VF中小波的寿命和动力学，使用一种新的相位映射方法，该方法可以识别各个小波的相位奇点（PS）。24例中有21例存在时空周期性。在24次发作中的3次中观察到心外膜表面完全折返。时空周期性离散区域的周期长度与光学伪心电图的主频（R-2=0.75）和全局双极电图（R-2=0.79）高度相关。PS的寿命很短（14.7+/-14.4 ms）; 98%的PS存在于
The mechanism(s) underlying ventricular fibrillation (VF) remain unclear. We hypothesized that at least some forms of VF are not random and that high-frequency periodic sources of activity manifest themselves as spatiotemporal periodicities, which drive VF. Twenty-four VF episodes from 8 Langendorff-perfused rabbit hearts were studied using high-resolution video imaging in conjunction with ECG recordings and spectral analysis. Sequential wavefronts that activated the ventricles in a spatially and temporally periodic fashion were identified. In addition, we analyzed the lifespan and dynamics of wavelets in VF, using a new method of phase mapping that enables identification of phase singularity points (PSs), which flank individual wavelets. Spatiotemporal periodicity was found in 21 of 24 episodes. Complete reentry on the epicardial surface was observed in 3 of 24 episodes. The cycle length of discrete regions of spatiotemporal periodicity correlated highly with the dominant frequency of the optical pseudo-ECG (R-2=0.75) and with the global bipolar electrogram (R-2=0.79). The lifespan of PSs was short (14.7+/-14.4 ms); 98% of PSs existed for