Resting-state synchrony between the retrosplenial cortex and anterior medial cortical structures relates to memory complaints in subjective cognitive impairment
Resting-state synchrony between the retrosplenial cortex and anterior medial cortical structures relates to memory complaints in subjective cognitive impairment
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DOI：
10.1016/j.neurobiolaging.2015.03.006
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发表时间：
2015-06
影响因子：
4.2
通讯作者：
F. Yasuno;H. Kazui;Akihide Yamamoto;N. Morita;K. Kajimoto;M. Ihara;A. Taguchi;K. Matsuoka;Jun Kosaka;Toshihisa Tanaka;Takashi Kudo;M. Takeda;K. Nagatsuka;H. Iida;T. Kishimoto
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文献类型：
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作者：
F. Yasuno;H. Kazui;Akihide Yamamoto;N. Morita;K. Kajimoto;M. Ihara;A. Taguchi;K. Matsuoka;Jun Kosaka;Toshihisa Tanaka;Takashi Kudo;M. Takeda;K. Nagatsuka;H. Iida;T. Kishimoto
主观认知功能障碍（subjective cognitive impairment，SCI）是一种以主观认知功能障碍为特征的临床状态。为了验证这一假设，即这种状态可能涉及功能障碍的自我参照处理皮层中线结构介导的，我们调查了这些结构的功能连接在个人与SCI使用静息态功能磁共振成像异常。我们对23名SCI患者和30名非SCI患者进行了功能连接分析。为了揭示功能连接变化的病理生理基础，我们进行了磁共振扩散张量成像。在13名SCI和15名非SCI受试者中进行了正电子发射断层扫描-淀粉样蛋白成像。SCI患者的皮质中线结构的功能连接性降低。白色连接的减少与功能连接的减少有关，但我们在SCI患者中没有发现淀粉样蛋白沉积。结果并不一定矛盾的可能性，SCI表明最初的认知递减，但意味着减少皮质中线结构的功能连接有助于高估的健忘的经验。
Subjective cognitive impairment (SCI) is a clinical state characterized by subjective cognitive deficits without cognitive impairment. To test the hypothesis that this state might involve dysfunction of self-referential processing mediated by cortical midline structures, we investigated abnormalities of functional connectivity in these structures in individuals with SCI using resting-state functional magnetic resonance imaging. We performed functional connectivity analysis for 23 individuals with SCI and 30 individuals without SCI. To reveal the pathophysiological basis of the functional connectivity change, we performed magnetic resonance-diffusion tensor imaging. Positron emission tomography-amyloid imaging was conducted in 13 SCI and 15 nonSCI subjects. Individuals with SCI showed reduced functional connectivity in cortical midline structures. Reduction in white matter connections was related to reduced functional connectivity, but we found no amyloid deposition in individuals with SCI. The results do not necessarily contradict the possibility that SCI indicates initial cognitive decrements, but imply that reduced functional connectivity in cortical midline structures contributes to overestimation of the experience of forgetfulness.