The roles of histone variants in fine-tuning chromatin organization and function.
The roles of histone variants in fine-tuning chromatin organization and function.
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DOI：
10.1038/s41580-020-0262-8
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发表时间：
2020-09
期刊：
影响因子：
--
通讯作者：
Banaszynski LA
中科院分区：
文献类型：
--
作者：
Martire S;Banaszynski LA
组蛋白在细胞核内包裹和组织DNA。除了组蛋白翻译后修饰和染色质重塑复合物外，组蛋白变异还增加了基因组表观遗传调控的复杂性。组蛋白变异的特点是具有独特的蛋白质序列和选择指定的伴侣系统和染色质重塑复合物，这些复合物调节其在基因组中的定位。此外，组蛋白变体可以通过特定的翻译后修饰而丰富，这反过来可以为变体特异性相互作用蛋白募集到染色质提供支架。因此，通过这些特性，组蛋白变体有能力以一种受调节的方式赋予染色质的特定区域独特的特征和功能。在这篇综述中，我们概述了在哺乳动物系统中组蛋白变异对染色质功能的贡献方面的最新进展。首先，我们讨论了伴侣介导的组蛋白变异沉积的新分子见解。接下来，我们将讨论组蛋白变异影响染色质特性的机制，如核小体稳定性和局部染色质环境，这两种机制都是通过组蛋白变异序列特异性效应和它们在募集不同染色质相关复合物中的作用来实现的。最后，我们关注组蛋白变异在胚胎发育和人类疾病，特别是发育综合征和癌症中的功能。
Histones serve to both package and organize DNA within the nucleus. In addition to histone post-translational modification and chromatin remodelling complexes, histone variants contribute to the complexity of epigenetic regulation of the genome. Histone variants are characterized by a distinct protein sequence and a selection of designated chaperone systems and chromatin remodelling complexes that regulate their localization in the genome. In addition, histone variants can be enriched with specific post-translational modifications, which in turn can provide a scaffold for recruitment of variant-specific interacting proteins to chromatin. Thus, through these properties, histone variants have the capacity to endow specific regions of chromatin with unique character and function in a regulated manner. In this Review, we provide an overview of recent advances in our understanding of the contribution of histone variants to chromatin function in mammalian systems. First, we discuss new molecular insights into chaperone-mediated histone variant deposition. Next, we discuss mechanisms by which histone variants influence chromatin properties such as nucleosome stability and the local chromatin environment both through histone variant sequence-specific effects and through their role in recruiting different chromatin-associated complexes. Finally, we focus on histone variant function in the context of both embryonic development and human disease, specifically developmental syndromes and cancer.
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影响因子：
64.5
作者：
Banaszynski LA;Wen D;Dewell S;Whitcomb SJ;Lin M;Diaz N;Elsässer SJ;Chapgier A;Goldberg AD;Canaani E;Rafii S;Zheng D;Allis CD
通讯作者：
Allis CD
影响因子：
14.9
作者：
Arimura Y;Ikura M;Fujita R;Noda M;Kobayashi W;Horikoshi N;Sun J;Shi L;Kusakabe M;Harata M;Ohkawa Y;Tashiro S;Kimura H;Ikura T;Kurumizaka H
通讯作者：
Kurumizaka H
影响因子：
56.9
作者：
Celeste, A;Petersen, S;Nussenzweig, A
通讯作者：
Nussenzweig, A
影响因子：
3.7
作者：
Clynes D;Jelinska C;Xella B;Ayyub H;Taylor S;Mitson M;Bachrati CZ;Higgs DR;Gibbons RJ
通讯作者：
Gibbons RJ
影响因子：
16.8
作者：
Buschbeck, Marcus;Uribesalgo, Iris;Di Croce, Luciano
通讯作者：
Di Croce, Luciano