Antifungal activity of simple compounds with maleic anhydride or dimethylmaleimide structure against Botrytis cinerea
Antifungal activity of simple compounds with maleic anhydride or dimethylmaleimide structure against Botrytis cinerea
复制标题
DOI：
10.1584/jpestics.d11-054
复制
发表时间：
2012-01-01
影响因子：
2.4
通讯作者：
Shen, Yinchu
中科院分区：
文献类型：
--
作者：
Li, Wei;Fan, Yongxian;Shen, Yinchu
具有马来酸酐或马来酰亚胺的化合物呈现出相当大的抗真菌活性，并且已经报道了几种马来酰亚胺衍生物具有边缘或零动物毒性活性。为了研究这些化合物中马来酸酐或马来酰亚胺结构的抗真菌活性，我们购买或合成了44个相关化合物，并研究了它们对番茄灰霉病菌的MIC。结果表明，大部分马来酸酐和马来酰亚胺对B具有一定的抑菌活性。灰叶2，3-二甲基马来酸酐具有最高的活性（MIC=3 μ g/mL）在27个简单的化合物与马来酸酐。同时，N-3，5-二氯苯胺-3，4-二甲基马来酰亚胺是17种马来酰亚胺衍生物中最好的（MIC=0.1 μ g/mL），其活性几乎与二氯乙烷的活性相当。此外，本文中的数据表明，极性和空间位阻的马来酸酐衍生物可以影响其抗真菌活性。(C)日本农药学会
Compounds with maleic anhydride or maleimide presented considerable antifungal activity, and several maleimide derivatives have been reported to possess marginal or null zootoxic activity. In order to research the antifungal activity of the maleic anhydride or maleimide structure in these compounds, 44 related compounds were purchased or synthesized, and their MICs against Botrytis cinerea were investigated. The results showed that most maleic anhydrides and maleimides presented antifungal activity against B. cinerea. 2,3-Dimethyl maleic anhydride had the highest activity (MIC=3 mu g/mL) among the 27 simple compounds with maleic anhydride. Meanwhile, N-3,5-dichloroaniline-3,4-dimethylmaleimide was the best (MIC=0.1 mu g/mL) of the 17 maleimide derivatives, with activities nearly equal to those of dichloran. Furthermore, the data in this article reveals that the polarity and steric hindrance of maleic anhydride derivatives could affect their antifungal activities. (C) Pesticide Science Society of Japan